N
Nikolaus J. Sucher
Researcher at Roxbury Community College
Publications - 103
Citations - 10966
Nikolaus J. Sucher is an academic researcher from Roxbury Community College. The author has contributed to research in topics: NMDA receptor & Protein subunit. The author has an hindex of 44, co-authored 103 publications receiving 10600 citations. Previous affiliations of Nikolaus J. Sucher include University College West & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
Stuart A. Lipton,Yun-Beom Choi,Yun-Beom Choi,Zhuo Hua Pan,Zhuo Hua Pan,Sizheng Z. Lei,Sizheng Z. Lei,Huei-Sheng Vincent Chen,Huei-Sheng Vincent Chen,Nikolaus J. Sucher,Nikolaus J. Sucher,Joseph Loscalzo,Joseph Loscalzo,David J. Singel,Jonathan S. Stamler,Jonathan S. Stamler +15 more
TL;DR: It is reported that NO.-mediated neurotoxicity is engendered, at least in part, by reaction with superoxide anion (O.-2), apparently leading to formation of peroxynitrite (ONOO−), and not by NO.
Journal ArticleDOI
Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex
Sizheng Z. Lei,Zhuo Hua Pan,Sanjay K. Aggarwal,Huei Sheng Vincent Chen,Jonathan Hartman,Nikolaus J. Sucher,Stuart A. Lipton,Stuart A. Lipton +7 more
TL;DR: The results demonstrate a new pathway for NO regulation of physiological function that is not via cGMP, but instead involves reactions with membrane-bound thiol groups on the NMDA receptor-channel complex.
Journal ArticleDOI
(S)NO signals: translocation, regulation, and a consensus motif.
TL;DR: Nitric oxide is a signaling molecule that has capin the immune system in work by DeGroote and Fang and the activation of bacterial resistance is achieved by by observations in the cardiovascular and immune sysS-nitrosylation of proteins involved in defense
Journal ArticleDOI
Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain
Nikolaus J. Sucher,Schahram Akbarian,CL Chi,CL Leclerc,Marc Awobuluyi,David L. Deitcher,MK Wu,JP Yuan,EG Jones,Stuart A. Lipton +9 more
TL;DR: Its developmental and regional expression pattern suggests that NMDAR-L may influence axonal outgrowth and synaptogenesis during brain development and in the adult brain, NMDar-L mRNA was detected predominately in the nucleus of the lateral olfactory tract.
Journal ArticleDOI
Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics
Schahram Akbarian,Nikolaus J. Sucher,D Bradley,Alireza Tafazzoli,D Trinh,William P. Hetrick,Steven G. Potkin,Curt A. Sandman,William E. Bunney,Edward G. Jones +9 more
TL;DR: Findings indicate regional heterogeneity of NMDA receptor subunit expression in human cerebral and cerebellar cortex and in schizophrenics, the alterations in expression of NR2 subunit mRNA in prefrontal cortex are potential indicators of deficits inNMDA receptor-mediated neurotransmission accompanying functional hypoactivity of the frontal lobes.