N
Nikolaus J. Sucher
Researcher at Roxbury Community College
Publications - 103
Citations - 10966
Nikolaus J. Sucher is an academic researcher from Roxbury Community College. The author has contributed to research in topics: NMDA receptor & Protein subunit. The author has an hindex of 44, co-authored 103 publications receiving 10600 citations. Previous affiliations of Nikolaus J. Sucher include University College West & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons.
Yasnory F. Sasaki,Yasnory F. Sasaki,Thomas Rothe,Thomas Rothe,Louis S. Premkumar,Saumya Das,Jiankun Cui,Maria Talantova,Hon-Kit Wong,Xiandi Gong,Shing Fai Chan,Dongxian Zhang,Dongxian Zhang,Dongxian Zhang,Nobuki Nakanishi,Nobuki Nakanishi,Nikolaus J. Sucher,Stuart A. Lipton,Stuart A. Lipton,Stuart A. Lipton +19 more
TL;DR: It is shown that recombinantly expressedNR3A in COS cells is biochemically associated with both NR1 and NR2 subunits, and whole cell NMDA-evoked currents are larger in NR3A-deficient mice compared with wild-type mice, and this effect follows a developmental pattern similar to that of NR3B protein expression on Western blots.
Journal ArticleDOI
Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain
Hon-Kit Wong,Xiao-Bo Liu,Maria F. Matos,Shing Fai Chan,Isabel Pérez-Otaño,Megan Boysen,Jiankun Cui,Nobuki Nakanishi,Nobuki Nakanishi,James S. Trimmer,Edward G. Jones,Stuart A. Lipton,Stuart A. Lipton,Stuart A. Lipton,Nikolaus J. Sucher +14 more
TL;DR: A comprehensive study to delineate the temporal and anatomic expression of NR3A protein in the mammalian brain by using a monoclonal anti‐NR3A antibody is reported, which will facilitate future research on NMDARs by providing clues to possible inclusion of the NR2A subunit in NMD ARs in many brain regions.
Journal ArticleDOI
Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development
Xiandi Gong,Nikolaus J. Sucher +1 more
TL;DR: How TCM provides an extensive and knowledge-rich foundation for implementing a strategically focused pharmacological research programme aimed at the development of new drugs is explained.
Journal ArticleDOI
Early Alterations of AMPA Receptors Mediate Synaptic Potentiation Induced by Neonatal Seizures
Sanjay N. Rakhade,Chengwen Zhou,Paven K. Aujla,Rachel E. Fishman,Nikolaus J. Sucher,Frances E. Jensen +5 more
TL;DR: Potential mechanisms that elucidate a critical role for AMPA receptors (AMPARs) in epileptogenesis during this critical period in the developing brain are identified and a novel therapeutic target in the highly seizure-prone developing brain is offered.
Journal ArticleDOI
Surface Characterization of a Silicon-Chip-Based DNA Microarray
TL;DR: The covalent immobilization of thiol-terminated DNA oligonucleotides on self-assembled layers of (3-mercaptopropyl)trimethoxysilane (MPTS) by disulfide bond formation was investigated.