Nimet Maherali

TL;DR: The generation of induced pluripotent stem cells from patients with a variety of genetic diseases with either Mendelian or complex inheritance are described, offering an unprecedented opportunity to recapitulate both normal and pathologic human tissue formation in vitro, thereby enabling disease investigation and drug development.

TL;DR: Genome-wide analysis of two key histone modifications indicated that iPS cells are highly similar to ES cells, and data show that transcription factor-induced reprogramming leads to the global reversion of the somatic epigenome into an ES-like state.

TL;DR: Using doxycycline-inducible vectors, it is shown that exogenous factors are required for about 10 days, after which cells enter a self-sustaining pluripotent state and markers are identified that define cell populations prior to and during this transition period.

TL;DR: The results show that the acquisition of immortality is a crucial and rate-limiting step towards the establishment of a pluripotent state in somatic cells and underscore the similarities between induced pluripotency and tumorigenesis.

TL;DR: This work sought to create a doxycycline-inducible lentiviral system to convert primary human fibroblasts and keratinocytes into human induced pluripotent stem cells (hiPSCs), and developed a strategy to induce hiPSC formation at high frequency.