J
James T. Sorrentino
Researcher at University of California, San Diego
Publications - 12
Citations - 174
James T. Sorrentino is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Medicine & Heparan sulfate. The author has an hindex of 5, co-authored 9 publications receiving 71 citations. Previous affiliations of James T. Sorrentino include University of California, Berkeley.
Papers
More filters
Journal ArticleDOI
Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis.
Alejandro Gomez Toledo,Gregory J. Golden,Alexandre Rosa Campos,Hector Cuello,James T. Sorrentino,Nathan E. Lewis,Nissi Varki,Victor Nizet,Victor Nizet,Jeffrey W. Smith,Jeffrey D. Esko +10 more
TL;DR: In vivo biotinylation and high-resolution mass spectrometry are combined to characterize organ-level changes of the murine vascular cell surface proteome induced by MRSA sepsis, indicating that MRSA-sepsis triggers extensive proteome remodeling of the vascular cell surfaces, in a tissue-specific manner.
Journal ArticleDOI
A Systems View of the Heparan Sulfate Interactome
Alejandro Gomez Toledo,Alejandro Gomez Toledo,James T. Sorrentino,Daniel R. Sandoval,Johan Malmström,Nathan E. Lewis,Jeffrey D. Esko +6 more
TL;DR: Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains as mentioned in this paper.
Posted ContentDOI
Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity
Cameron Martino,Cameron Martino,Benjamin P. Kellman,Benjamin P. Kellman,Daniel R. Sandoval,Thomas Mandel Clausen,Thomas Mandel Clausen,Clarisse Marotz,Se Jin Song,Stephen Wandro,Livia S. Zaramela,Rodolfo Salido Benitez,Rodolfo Salido Benitez,Qiyun Zhu,Erick Armingol,Erick Armingol,Erick Armingol,Yoshiki Vázquez-Baeza,Yoshiki Vázquez-Baeza,Daniel McDonald,Daniel McDonald,James T. Sorrentino,James T. Sorrentino,Bryn C. Taylor,Pedro Belda-Ferre,Chenguang Liang,Chenguang Liang,Yujie Zhang,Luca Schifanella,Nichole R. Klatt,Aki S. Havulinna,Aki S. Havulinna,Pekka Jousilahti,Shi Huang,Shi Huang,Niina Haiminen,Laxmi Parida,Ho-Cheol Kim,Austin D. Swafford,Karsten Zengler,Karsten Zengler,Susan Cheng,Susan Cheng,Michael Inouye,Michael Inouye,Teemu J. Niiranen,Teemu J. Niiranen,Mohit Jain,Veikko Salomaa,Jeffrey D. Esko,Nathan E. Lewis,Nathan E. Lewis,Nathan E. Lewis,Rob Knight +53 more
TL;DR: It is shown that commensal host bacterial communities can modify HS and thereby modulate SARS-CoV-2 spike protein binding and that these communities change with host age and sex.
Journal ArticleDOI
A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering
Chenguang Liang,Austin W. T. Chiang,Anders Holmgaard Hansen,Johnny Arnsdorf,Sanne Schoffelen,James T. Sorrentino,Benjamin P. Kellman,Bokan Bao,Bjørn G. Voldborg,Nathan E. Lewis +9 more
TL;DR: This modeling approach enables rational glycoengineering and the elucidation of relationships between glycosyltransferases, thereby facilitating biopharmaceutical research and aiding the broader study of Glycosylation to elucidate the genetic basis of complex changes in glycosYLation.
Journal ArticleDOI
Correcting for sparsity and interdependence in glycomics by accounting for glycan biosynthesis.
Bokan Bao,Benjamin P. Kellman,Austin W. T. Chiang,Yujie Zhang,James T. Sorrentino,Austin K. York,Mahmoud A. Mohammad,Morey W. Haymond,Lars Bode,Nathan E. Lewis +9 more
TL;DR: GlyCompare as discussed by the authors uses shared biosynthetic steps for all measured glycans to correct for sparsity and non-independence in glycomics, which enables direct comparison of different glycoprofiles and increases statistical power.