D
David Goulding
Researcher at Wellcome Trust Sanger Institute
Publications - 99
Citations - 8042
David Goulding is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Salmonella enterica & Bacteriophage. The author has an hindex of 40, co-authored 98 publications receiving 6834 citations.
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Journal ArticleDOI
Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation
Hilary P. Browne,Samuel C. Forster,Samuel C. Forster,Samuel C. Forster,Blessing O. Anonye,Nitin Kumar,B. Anne Neville,Mark D. Stares,David Goulding,Trevor D. Lawley +9 more
TL;DR: A novel workflow based on targeted phenotypic culturing linked to large-scale whole-genome sequencing, phylogenetic analysis and computational modelling demonstrates that a substantial proportion of the intestinal bacteria are culturable and reveals how a marked proportion of oxygen-sensitive intestinal bacteria can be transmitted between individuals, affecting microbiota heritability.
Journal ArticleDOI
IFITM3 restricts the morbidity and mortality associated with influenza
Aaron R. Everitt,Simon Clare,Thomas Pertel,Sinu P. John,Rachael S. Wash,Sarah E. Smith,Christopher R. Chin,Eric M. Feeley,Jennifer S. Sims,David J. Adams,Helen M. Wise,Leanne Kane,David Goulding,Paul Digard,Verneri Anttila,J Kenneth Baillie,Timothy S. Walsh,David A. Hume,Aarno Palotie,Yali Xue,Vincenza Colonna,Vincenza Colonna,Chris Tyler-Smith,Jake Dunning,Stephen B. Gordon,Rosalind L. Smyth,Peter J. M. Openshaw,Gordon Dougan,Abraham L. Brass,Abraham L. Brass,Paul Kellam,Paul Kellam +31 more
TL;DR: Data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans.
Journal ArticleDOI
Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice
Trevor D. Lawley,Simon Clare,Alan W. Walker,Mark D. Stares,Thomas R. Connor,Claire Raisen,David Goulding,Roland Rad,Fernanda Schreiber,Cordelia Brandt,Laura J. Deakin,Derek Pickard,Sylvia H. Duncan,Harry J. Flint,Taane G. Clark,Julian Parkhill,Gordon Dougan +16 more
TL;DR: A rational approach to harness the therapeutic potential of health-associated microbial communities to treat C. difficile disease and potentially other forms of intestinal dysbiosis is demonstrated.
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Juno is the egg Izumo receptor and is essential for mammalian fertilization
TL;DR: It is shown that the Izumo1–Juno interaction is conserved within several mammalian species, including humans, and it is proposed to rename it Juno to provide opportunities for the rational development of new fertility treatments and contraceptives.
Journal ArticleDOI
Antibiotic treatment of Clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts.
Trevor D. Lawley,Simon Clare,Alan W. Walker,David Goulding,Richard A. Stabler,Nicholas J. Croucher,Piero Mastroeni,Paul Scott,Claire Raisen,Lynda Mottram,Neil F. Fairweather,Brendan W. Wren,Julian Parkhill,Gordon Dougan +13 more
TL;DR: Mice can be used to investigate distinct stages of the C. difficile infection cycle and can serve as a valuable surrogate for studying the spore-mediated transmission and interactions between C. Difficile and the host and its microbiota, and the results obtained should guide infection control measures.