N
Nobutaka Suzuki
Researcher at University of Toronto
Publications - 12
Citations - 3302
Nobutaka Suzuki is an academic researcher from University of Toronto. The author has contributed to research in topics: Signal transduction & Innate immune system. The author has an hindex of 12, co-authored 12 publications receiving 3157 citations. Previous affiliations of Nobutaka Suzuki include Ontario Institute for Cancer Research.
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Journal ArticleDOI
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
Nobutaka Suzuki,Shinobu Suzuki,Gordon S. Duncan,Douglas G. Millar,Teiji Wada,Christine Mirtsos,Hidetoshi Takada,Andrew Wakeham,Annick Itie,Shyun Li,Josef M. Penninger,Holger Wesche,Pamela S. Ohashi,Tak W. Mak,Wen Chen Yeh +14 more
TL;DR: It is shown by gene-targeting that IRAK-4, an IRAK molecule closely related to the Drosophila Pelle protein, is indispensable for the responses of animals and cultured cells to IL-1 and ligands that stimulate various TLRs.
Journal ArticleDOI
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling
Kenya Honda,Hideyuki Yanai,Tatsuaki Mizutani,Hideo Negishi,Naoya Shimada,Nobutaka Suzuki,Yusuke Ohba,Akinori Takaoka,Wen Chen Yeh,Tadatsugu Taniguchi +9 more
TL;DR: The complex defined in this study represents an example of how the coupling of the signaling adaptor and effector kinase molecules together with the transcription factor regulate the processing of an extracellular signal to evoke its versatile downstream transcriptional events in a cell.
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Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development
Wen-Chen Yeh,Annick Itie,Andrew J. Elia,Michelle Ng,Hong-Bing Shu,Andrew Wakeham,Christine Mirtsos,Nobutaka Suzuki,Madeleine Bonnard,David V. Goeddel,Tak W. Mak +10 more
TL;DR: It is suggested that Casper has two distinct roles: to cooperate with FADD and caspase-8 during embryonic development and to mediate cytoprotection against death factor-induced apoptosis.
Journal ArticleDOI
Toll-like Receptors Induce a Phagocytic Gene Program through p38
Sean E. Doyle,Ryan M. O'Connell,Gustavo A. Miranda,Sagar A. Vaidya,Edward Kai-Hua Chow,Philip T. Liu,Shinobu Suzuki,Nobutaka Suzuki,Robert L. Modlin,Wen Chen Yeh,Timothy F. Lane,Genhong Cheng +11 more
TL;DR: It is demonstrated that TLR ligands not only amplify the percentage of phagocytes uptaking Escherichia coli, but also increase the number of bacteria phagocytosed by individual macrophages, describing an evolutionarily conserved mechanism by which TLRs can specifically promote phagocyte clearance of bacteria during infection.
Journal ArticleDOI
IRAK-4 as the central TIR signaling mediator in innate immunity
TL;DR: Surprisingly, gene targeting studies show that the newest IRAK protein, IRAK-4, has an essential role in mediating signals initiated by IL-1R and TLR engagement.