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Shinobu Suzuki
Researcher at University of Toronto
Publications - 13
Citations - 2861
Shinobu Suzuki is an academic researcher from University of Toronto. The author has contributed to research in topics: Receptor & Signal transduction. The author has an hindex of 11, co-authored 13 publications receiving 2707 citations. Previous affiliations of Shinobu Suzuki include Ontario Institute for Cancer Research & University Health Network.
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Journal ArticleDOI
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
Nobutaka Suzuki,Shinobu Suzuki,Gordon S. Duncan,Douglas G. Millar,Teiji Wada,Christine Mirtsos,Hidetoshi Takada,Andrew Wakeham,Annick Itie,Shyun Li,Josef M. Penninger,Holger Wesche,Pamela S. Ohashi,Tak W. Mak,Wen Chen Yeh +14 more
TL;DR: It is shown by gene-targeting that IRAK-4, an IRAK molecule closely related to the Drosophila Pelle protein, is indispensable for the responses of animals and cultured cells to IL-1 and ligands that stimulate various TLRs.
Journal ArticleDOI
Toll-like Receptors Induce a Phagocytic Gene Program through p38
Sean E. Doyle,Ryan M. O'Connell,Gustavo A. Miranda,Sagar A. Vaidya,Edward Kai-Hua Chow,Philip T. Liu,Shinobu Suzuki,Nobutaka Suzuki,Robert L. Modlin,Wen Chen Yeh,Timothy F. Lane,Genhong Cheng +11 more
TL;DR: It is demonstrated that TLR ligands not only amplify the percentage of phagocytes uptaking Escherichia coli, but also increase the number of bacteria phagocytosed by individual macrophages, describing an evolutionarily conserved mechanism by which TLRs can specifically promote phagocyte clearance of bacteria during infection.
Journal ArticleDOI
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF‐κB‐dependent gene transcription
Madeleine Bonnard,Christine Mirtsos,Shinobu Suzuki,Kevin Graham,Jianing Huang,Michelle Ng,Annick Itie,Andrew Wakeham,Arda Shahinian,William J. Henzel,Andrew J. Elia,Wendy Shillinglaw,Tak W. Mak,Zhaodan Cao,Wen-Chen Yeh +14 more
TL;DR: A novel kinase (T2K), which associates with TRAF2 and exhibits kinase activity towards I‐κBα in vitro, is demonstrated to be critical in protecting embryonic liver from apoptosis and has a unique role in the activation of NF‐kkB‐directed transcription.
Journal ArticleDOI
The MAGUK family protein CARD11 is essential for lymphocyte activation.
Hiromitsu Hara,Teiji Wada,Teiji Wada,Chris Bakal,Ivona Kozieradzki,Ivona Kozieradzki,Shinobu Suzuki,Nobutaka Suzuki,Mai Nghiem,Mai Nghiem,Emily K. Griffiths,Emily K. Griffiths,Connie M. Krawczyk,Connie M. Krawczyk,Birgit Bauer,Fulvio D'Acquisto,Sankar Ghosh,Wen Chen Yeh,Gottfried Baier,Robert Rottapel,Josef M. Penninger,Josef M. Penninger +21 more
TL;DR: The results show that the same family of molecules are critical regulators of neuronal synapses and immune receptor signaling.
Journal ArticleDOI
IRAK-4 as the central TIR signaling mediator in innate immunity
TL;DR: Surprisingly, gene targeting studies show that the newest IRAK protein, IRAK-4, has an essential role in mediating signals initiated by IL-1R and TLR engagement.