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Nunzio Iraci
Researcher at University of Salerno
Publications - 52
Citations - 1775
Nunzio Iraci is an academic researcher from University of Salerno. The author has contributed to research in topics: Docking (molecular) & Integrase. The author has an hindex of 26, co-authored 52 publications receiving 1488 citations. Previous affiliations of Nunzio Iraci include Katholieke Universiteit Leuven & University of Perugia.
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Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity
Luca Sancineto,Alice Mariotti,Luana Bagnoli,Francesca Marini,Jenny Desantis,Nunzio Iraci,Claudio Santi,Christophe Pannecouque,Oriana Tabarrini +8 more
TL;DR: A series of 2,2'-diselenobisbenzoic scaffold, amino acid, and benzenesulfonamide derivatives are identified as novel HIV retroviral nucleocapsid protein 7 (NCp7) inhibitors and their mechanism of action is based on NCp7 inhibition.
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Pharmacophore-Based Discovery of Small-Molecule Inhibitors of Protein–Protein Interactions between HIV-1 Integrase and Cellular Cofactor LEDGF/p75
Laura De Luca,Maria Letizia Barreca,Stefania Ferro,Frauke Christ,Nunzio Iraci,Rosaria Gitto,Anna Maria Monforte,Zeger Debyser,Alba Chimirri +8 more
TL;DR: This study finds a new and more potent small molecule that is able to interfere with the HIV‐1 IN–LEDGF/p75 interaction at micromolar concentration, representing one of the first compounds to show activity against these specific PPIs.
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A Highly Intensified ART Regimen Induces Long-Term Viral Suppression and Restriction of the Viral Reservoir in a Simian AIDS Model
Iart Luca Shytaj,Sandro Norelli,Barbara Chirullo,Alessandro Della Corte,Matt Collins,Jake Yalley-Ogunro,Jack Greenhouse,Nunzio Iraci,Edward P. Acosta,Maria Letizia Barreca,Mark G. Lewis,Andrea Savarino +11 more
TL;DR: This work shows, for the first time, complete suppression of viral load by highly intensified ART and a likely associated restriction of the viral reservoir in the macaque AIDS model, making it a useful platform for testing potential cures for AIDS.
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Pyrazolo[4,3-c][1,2]benzothiazines 5,5-Dioxide: A Promising New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors
Stefano Sabatini,Francesca Gosetto,Serena Serritella,Giuseppe Manfroni,Oriana Tabarrini,Nunzio Iraci,Jean-Pierre Brincat,Emanuele Carosati,Milena Villarini,Glenn W. Kaatz,Violetta Cecchetti +10 more
TL;DR: The EPI activity of the COX-2 inhibitor celecoxib was confirmed and a new class of pyrazolo[4,3-c][1,2]benzothiazine 5,5-dioxide analogues acting as inhibitors of the Staphylococcus aureus NorA multidrug efflux pump was identified.
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Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.
Maria Letizia Barreca,Angela Rao,Laura De Luca,Nunzio Iraci,Anna-Maria Monforte,Giovanni Maga,Erik De Clercq,Christophe Pannecouque,Jan Balzarini,Alba Chimirri +9 more
TL;DR: The rational discovery of N(1)-arylsulfonyl-1,3-dihydro-2H-benzimidazol-2-one as a novel template for the design of new non-nucleoside reverse transcriptase inhibitors (NNRTIs) that are active against wild-type and mutant strains of HIV-1 was found.