Onyi N. Irrechukwu

TL;DR: The ability of NIRS to monitor macromolecular content of cartilage constructs is demonstrated and is the first step towards employing NIR to assess engineered cartilage in situ.

TL;DR: The results demonstrate the feasibility of performing imaging‐based multiexponential analysis of transverse relaxation data to map PG in cartilage and demonstrate the accuracy and precision of the determination was within 2%, which is well‐within the observed tissue differences.

TL;DR: Two new approaches for the evaluation of tissue engineered constructs using MR provide improved sensitivity to changes in matrix development and specificity to matrix composition in tissue engineered cartilage and for extension to other tissue engineering constructs.

TL;DR: Results, combined with the previous investigation of Gaussian cluster‐based tissue discrimination, indicate that the combinations (T1, km) and (T 1, km, ADC) may emerge as particularly useful for characterization of early cartilage degradation.

TL;DR: In this article , the authors evaluated 870 Liver-Chips to determine their ability to predict drug-induced liver injury caused by small molecules identified as benchmarks by the Innovation and Quality consortium, who has published guidelines defining criteria for qualifying preclinical models.