K
Kenneth W. Fishbein
Researcher at National Institutes of Health
Publications - 92
Citations - 7409
Kenneth W. Fishbein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Skeletal muscle & Cartilage. The author has an hindex of 28, co-authored 85 publications receiving 6750 citations.
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Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
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Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
Magdalena Juhaszova,Dmitry B. Zorov,Dmitry B. Zorov,Suhn-Hee Kim,Suhn-Hee Kim,Salvatore Pepe,Salvatore Pepe,Qin Fu,Kenneth W. Fishbein,Bruce D. Ziman,Su Wang,Kirsti Ytrehus,Christopher L. Antos,Eric N. Olson,Steven J. Sollott +14 more
TL;DR: It is shown that reoxygenation after prolonged hypoxia reduces the reactive oxygen species (ROS) threshold for the mitochondrial permeability transition (MPT) in cardiomyocytes and that cell survival is steeply negatively correlated with the fraction of depolarized mitochondria.
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Multicomponent T2 relaxation analysis in cartilage.
TL;DR: The potential of multiexponential T2 analysis to increase the specificity of MR characterization of cartilage is demonstrated and the expected experimental accuracy of measured T2s and associated weights was within 2% and 4% respectively, with precision within 1% and 3%.
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Adenovirus-Mediated VEGF121 Gene Transfer Stimulates Angiogenesis in Normoperfused Skeletal Muscle and Preserves Tissue Perfusion After Induction of Ischemia
Luis Henrique W. Gowdak,Lioubov Poliakova,Xiaotong Wang,Imre Kovesdi,Kenneth W. Fishbein,Antonella Zacheo,Roberta Palumbo,Stefania Straino,Costanza Emanueli,Massimiliano Marrocco-Trischitta,Edward G. Lakatta,Piero Anversa,Richard G. Spencer,Mark I. Talan,Maurizio C. Capogrossi +14 more
TL;DR: IM administration of AdCMV.VEGF(121) stimulates angiogenesis in normoperfused skeletal muscles, and the newly formed vessels preserve TP after induction of ischemia.
Journal ArticleDOI
Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice
Annie Mirsoian,Myriam N. Bouchlaka,Gail D. Sckisel,Mingyi Chen,Chien-Chun Steven Pai,Emanual Michael Maverakis,Richard G. Spencer,Kenneth W. Fishbein,Sana Siddiqui,Arta M. Monjazeb,Bronwen Martin,Stuart Maudsley,Charles Hesdorffer,Luigi Ferrucci,Dan L. Longo,Bruce R. Blazar,Robert H. Wiltrout,Dennis D. Taub,Dennis D. Taub,William J. Murphy +19 more
TL;DR: It is shown that in addition to age, increased body fat is critical to this adverse reaction, as aged calorie-restricted mice demonstrate protection from IT-induced toxicity.