Orna Man

TL;DR: It is found that the patterns of evolution in human and chimpanzee protein-coding genes are highly correlated and dominated by the fixation of neutral and slightly deleterious alleles.

TL;DR: An easy-to-use, versatile and freely available graphic web server, FoldIndex© predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence.

TL;DR: A missense mutation in a highly conserved region of the calsequestrin 2 gene (CASQ2) is described as the potential cause of the autosomal recessive form ofatecholamine-induced polymorphic ventricular tachycardia.

TL;DR: It is found that humans have accumulated mutations that disrupt OR coding regions roughly 4-fold faster than any other species sampled, suggesting a human-specific process of OR gene disruption, likely due to a reduced chemosensory dependence relative to apes.

TL;DR: It is found that Mendelian-disease genes appear to be under widespread purifying selection, especially when the disease mutations are dominant (rather than recessive) and the class of genes that influence complex-Disease risk shows little signs of evolutionary conservation.