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Ines Hellmann
Researcher at Ludwig Maximilian University of Munich
Publications - 60
Citations - 14825
Ines Hellmann is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Gene & Population. The author has an hindex of 35, co-authored 57 publications receiving 13224 citations. Previous affiliations of Ines Hellmann include Max F. Perutz Laboratories & University of California, Berkeley.
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Journal ArticleDOI
Initial sequence of the chimpanzee genome and comparison with the human genome
Tarjei S. Mikkelsen,LaDeana W. Hillier,Evan E. Eichler,Michael C. Zody,David B. Jaffe,Shiaw-Pyng Yang,Wolfgang Enard,Ines Hellmann,Kerstin Lindblad-Toh,Tasha K. Altheide,Nicoletta Archidiacono,Peer Bork,Jonathan Butler,Jean L. Chang,Ze Cheng,Asif T. Chinwalla,Pieter J. de Jong,Kimberley D. Delehaunty,Catrina Fronick,Lucinda L. Fulton,Yoav Gilad,Gustavo Glusman,Sante Gnerre,Tina Graves,Toshiyuki Hayakawa,Karen E. Hayden,Xiaoqiu Huang,Hongkai Ji,W. James Kent,Mary Claire King,Edward J. Kulbokasl,Ming K. Lee,Ge Liu,Carlos López-Otín,Kateryna D. Makova,Orna Man,Elaine R. Mardis,Evan Mauceli,Tracie L. Miner,William E. Nash,Joanne O. Nelson,Svante Pääbo,Nick Patterson,Craig Pohl,Katherine S. Pollard,Kay Prüfer,Xose S. Puente,David Reich,Mariano Rocchi,Kate R. Rosenbloom,Maryellen Ruvolo,Daniel J. Richter,Stephen F. Schaffner,Arian F.A. Smit,Scott M. Smith,Mikita Suyama,James E. Taylor,David Torrents,Eray Tüzün,Ajit Varki,Gloria Velasco,Mario Ventura,John W. Wallis,Michael C. Wendl,Richard K. Wilson,Eric S. Lander,Robert H. Waterston +66 more
TL;DR: It is found that the patterns of evolution in human and chimpanzee protein-coding genes are highly correlated and dominated by the fixation of neutral and slightly deleterious alleles.
Journal ArticleDOI
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome.
Michael Weber,Ines Hellmann,Michael B. Stadler,Liliana Ramos,Svante Pääbo,Michael Rebhan,Dirk Schübeler +6 more
TL;DR: Results show that promoter sequence and gene function are major predictors of promoter methylation states and that inactive unmethylated CpG island promoters show elevated levels of dimethylation of Lys4 of histone H3, suggesting that this chromatin mark may protect DNA from methylation.
Journal ArticleDOI
The complete genome sequence of a Neanderthal from the Altai Mountains
Kay Prüfer,Fernando Racimo,Nick Patterson,Flora Jay,Sriram Sankararaman,Susanna Sawyer,Anja Heinze,Gabriel Renaud,Peter H. Sudmant,Cesare de Filippo,Heng Li,Swapan Mallick,Michael Dannemann,Qiaomei Fu,Martin Kircher,Martin Kuhlwilm,Michael Lachmann,Matthias Meyer,Matthias Ongyerth,Michael Siebauer,Christoph Theunert,Arti Tandon,Priya Moorjani,Joseph K. Pickrell,James C. Mullikin,Samuel H. Vohr,Richard E. Green,Ines Hellmann,Philip L. F. Johnson,Hélène Blanché,Howard M. Cann,Jacob O. Kitzman,Jay Shendure,Evan E. Eichler,Ed S. Lein,Trygve E. Bakken,Liubov V. Golovanova,Vladimir B. Doronichev,Michael V. Shunkov,A.P. Derevianko,Bence Viola,Montgomery Slatkin,David Reich,Janet Kelso,Svante Pääbo +44 more
TL;DR: It is shown that interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene and a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans is established.
Journal ArticleDOI
Comparative Analysis of Single-Cell RNA Sequencing Methods.
Christoph Ziegenhain,Beate Vieth,Swati Parekh,Björn Reinius,Amy Guillaumet-Adkins,Martha Smets,Heinrich Leonhardt,Holger Heyn,Ines Hellmann,Wolfgang Enard +9 more
TL;DR: Power simulations at different sequencing depths showed that Drop-seq is more cost-efficient for transcriptome quantification of large numbers of cells, while MARS-seq, SCRB- sequencing, and Smart-seq2 are more efficient when analyzing fewer cells.
Journal ArticleDOI
The diploid genome sequence of an Asian individual.
Jun Wang,Wei Wang,Ruiqiang Li,Ruiqiang Li,Yingrui Li,Yingrui Li,Yingrui Li,Geng Tian,Geng Tian,Laurie Goodman,Wei Fan,Junqing Zhang,Jun Li,Juanbin Zhang,Yiran Guo,Yiran Guo,Binxiao Feng,Heng Li,Heng Li,Yao Lu,Xiaodong Fang,Huiqing Liang,Zhenglin Du,Dong Li,Yiqing Zhao,Yiqing Zhao,Yujie Hu,Yujie Hu,Zhenzhen Yang,Hancheng Zheng,Ines Hellmann,Michael Inouye,John E. Pool,Xin Yi,Xin Yi,Jing Zhao,Jinjie Duan,Yan Zhou,Junjie Qin,Junjie Qin,Lijia Ma,Lijia Ma,Guoqing Li,Zhentao Yang,Guojie Zhang,Guojie Zhang,Bin Yang,Chang Yu,Fang Liang,Fang Liang,Wenjie Li,Shaochuan Li,Dawei Li,Peixiang Ni,Jue Ruan,Jue Ruan,Qibin Li,Qibin Li,Hongmei Zhu,Dongyuan Liu,Zhike Lu,Ning Li,Ning Li,Guangwu Guo,Guangwu Guo,Jianguo Zhang,Jia Ye,Lin Fang,Qin Hao,Qin Hao,Quan Chen,Quan Chen,Yu Liang,Yu Liang,Yeyang Su,Yeyang Su,A. san,A. san,Cuo Ping,Cuo Ping,Shuang Yang,Fang Chen,Fang Chen,Li Li,Ke Zhou,Hongkun Zheng,Hongkun Zheng,Yuanyuan Ren,Ling Yang,Yang Gao,Yang Gao,Guohua Yang,Guohua Yang,Zhuo Li,Xiaoli Feng,Karsten Kristiansen,Gane Ka-Shu Wong,Gane Ka-Shu Wong,Rasmus Nielsen,Richard Durbin,Lars Bolund,Lars Bolund,Xiuqing Zhang,Xiuqing Zhang,Songgang Li,Songgang Li,Songgang Li,Huanming Yang,Huanming Yang,Jian Wang,Jian Wang +110 more
TL;DR: Genotyping analysis showed that SNP identification had high accuracy and consistency, indicating the high sequence quality of this assembly, and the potential usefulness of next-generation sequencing technologies for personal genomics.