O
Otto C. Boerman
Researcher at Radboud University Nijmegen
Publications - 358
Citations - 17532
Otto C. Boerman is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Radioimmunotherapy & In vivo. The author has an hindex of 66, co-authored 355 publications receiving 15882 citations. Previous affiliations of Otto C. Boerman include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Digitalis-like Compounds Facilitate Non-Medullary Thyroid Cancer Redifferentiation through Intracellular Ca2+, FOS, and Autophagy-Dependent Pathways
Marika H Tesselaar,Thomas Crezee,Herman G.P. Swarts,Danny Gerrits,Otto C. Boerman,Jan B. Koenderink,Hendrik G. Stunnenberg,Mihai G. Netea,Johannes W. A. Smit,Romana T. Netea-Maier,Theo S. Plantinga +10 more
TL;DR: Five autophagy-activating compounds, all known as digitalis-like compounds, restored hNIS expression and iodide uptake in thyroid cancer cell lines and could represent a promising repositioned treatment modality for patients with RAI-refractory thyroid carcinoma.
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In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow
Laurens T. van der Meer,Samantha Y.A. Terry,Samantha Y.A. Terry,Dorette van Ingen Schenau,Kiki C. Andree,Gerben M. Franssen,Debbie M. Roeleveld,Josbert M. Metselaar,Thomas Reinheckel,Peter M. Hoogerbrugge,Otto C. Boerman,Frank N. van Leeuwen +11 more
TL;DR: In vivo imaging and biodistribution studies showed a rapid accumulation of asparaginase in macrophage-rich tissues such as the liver, spleen, and in particular bone marrow, which may provide a protective niche to leukemic cells.
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(99m)Tc-E-selectin binding peptide for imaging acute osteomyelitis in a novel rat model.
S. Gratz,Martin Béhé,Otto C. Boerman,E. Kunze,H.L. Schulz,H. Eiffert,T. O'Reilly,T. M. Behr,C. Angerstein,K. Nebendahl,F. Kauer,Wolfgang Becker +11 more
TL;DR: 99mTc-IMP-178 allows imaging of an acute osteomyelitic lesions, presumably by interaction of 99mTl-radiolabelled E-selectin binding peptide with activated upregulated vascular endothelium.
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Graft revascularization is essential for non-invasive monitoring of transplanted islets with radiolabeled exendin
TL;DR: The importance of islet vasculature for in vivo delivery of radiotracers to transplanted islets is demonstrated and it is demonstrated that optimal and stable uptake of exendin four weeks after transplantation opens the possibility for long-term monitoring of islets survival by SPECT imaging.
Journal ArticleDOI
Perfluorocarbon/Gold Loading for Noninvasive in Vivo Assessment of Bone Fillers Using 19F Magnetic Resonance Imaging and Computed Tomography
Simone Mastrogiacomo,Weiqiang Dou,Olga Koshkina,Otto C. Boerman,John A. Jansen,Arend Heerschap,Mangala Srinivas,X. Frank Walboomers +7 more
TL;DR: An easy and efficient strategy for following CPC implantation and degradation in vivo is developed as all materials used are biocompatible and this CPC/PFCE/gold composite is clinically applicable.