O
Otto C. Boerman
Researcher at Radboud University Nijmegen
Publications - 358
Citations - 17532
Otto C. Boerman is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Radioimmunotherapy & In vivo. The author has an hindex of 66, co-authored 355 publications receiving 15882 citations. Previous affiliations of Otto C. Boerman include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
PET of EGFR with (64) Cu-cetuximab-F(ab')2 in mice with head and neck squamous cell carcinoma xenografts.
Laura K. van Dijk,Cheng-Bin Yim,Gerben M. Franssen,Johannes H.A.M. Kaanders,Johan Rajander,Olof Solin,Olof Solin,Tove J. Grönroos,Otto C. Boerman,Johan Bussink +9 more
TL;DR: Clinically, this tracer has the potential to be used to determine cetuximab targeting of tumors and possibly to non-invasively monitor the response to EGFR-inhibitor treatment and is a promising PET tracer to determine expression of EGFR in vivo.
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Upregulation of IGF-1R Expression during Neoadjuvant Therapy Predicts Poor Outcome in Breast Cancer Patients
Sandra Heskamp,Otto C. Boerman,Janneke D.M. Molkenboer-Kuenen,Carla Wauters,Luc J. A. Strobbe,Caroline M.P.W. Mandigers,Peter Bult,Wim J.G. Oyen,Winette T. A. van der Graaf,Hanneke W. M. van Laarhoven +9 more
TL;DR: Upregulation of IGF-1R expression after neoadjuvant treatment is a poor prognostic factor in breast cancer patients, providing a rationale for incorporating anti-IGF-1r drugs in the management of these patients.
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Improved Intraoperative Detection of Ovarian Cancer by Folate Receptor Alpha Targeted Dual-Modality Imaging.
Marlène C.H. Hekman,Otto C. Boerman,Desiree Bos,Leon F.A.G. Massuger,Susan C. Weil,Luigi Grasso,Katherine Rybinski,Egbert Oosterwijk,Peter F.A. Mulders,Mark Rijpkema +9 more
TL;DR: FRα-targeted SPECT/fluorescence imaging using 111In-farletuzumab-IRDye800CW can be used to detect ovarian cancer in vivo and could be a valuable tool for enhanced intraoperative tumor visualization in patients with intraperitoneal metastases of ovarian cancer.
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Liposomal Treatment of Experimental Arthritis Can Be Monitored Noninvasively with a Radiolabeled Anti-Fibroblast Activation Protein Antibody
Tessa van der Geest,Peter Laverman,Danny Gerrits,Birgitte Walgreen,Monique H Helsen,Christian Klein,Tapan K. Nayak,Gert Storm,Josbert M. Metselaar,Marije I. Koenders,Otto C. Boerman +10 more
TL;DR: SPECT/CT imaging with 99mTc-S-HYNIC-28H1 specifically monitored the response to therapy, and tracer accumulation correlated with the severity of inflammation, indicating that SPECT/ CT imaging might be more sensitive than the macroscopic arthritis scoring method.
Journal ArticleDOI
Tumor retention of 186Re-MAG3, 111In-DTPA and 125I labeled monoclonal antibody G250 in nude mice with renal cell carcinoma xenografts.
Martijn G Steffens,M.H.G.C. Kranenborg,Otto C. Boerman,N.E.M. Zegwaart-Hagemeier,Frans M.J. Debruyne,Frans H.M. Corstens,Egbert Oosterwijk +6 more
TL;DR: In contrast to other radiometals such as 111In and 90Y, 186Re is not retained in the tumor cell, therefore 186Re has no additional advantage for radioimmunotherapy with respect to retention in the tumors.