P
P. Andrew Futreal
Researcher at University of Texas at Austin
Publications - 32
Citations - 11582
P. Andrew Futreal is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Breast cancer & Tumor suppressor gene. The author has an hindex of 18, co-authored 32 publications receiving 10098 citations. Previous affiliations of P. Andrew Futreal include Howard Hughes Medical Institute & Wellcome Trust.
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Journal ArticleDOI
Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers
G. Larry Maxwell,John I. Risinger,Betty C. Tong,Heather S. Shaw,J. Carl Barrett,Andrew Berchuck,P. Andrew Futreal +6 more
TL;DR: Alteration of the PTEN tumor suppressor gene does not appear to be a feature of sporadic or BRCA1-associated ovarian cancers.
Journal ArticleDOI
The human mammary-derived growth inhibitor (MDGI) gene: genomic structure and mutation analysis in human breast tumors.
Catherine M. Phelan,Catherine M. Phelan,Catharina Larsson,Stephen Baird,P. Andrew Futreal,M.H. Ruttledge,Kenneth Morgan,Patricia N. Tonin,Huynh Hung,Robert G. Korneluk,Michael Pollak,Steven A. Narod +11 more
TL;DR: The data suggest that mutations in the coding region are uncommon in human breast tumorigenesis, and the human MDGI gene has been mapped to human chromosome 1p32-p35, a common region of deletion in sporadic breast tumors.
Journal ArticleDOI
Improving the detection of patients with inherited predispositions to hematologic malignancies using next-generation sequencing-based leukemia prognostication panels.
Courtney D. DiNardo,Mark J. Routbort,Sarah A. Bannon,Christopher B. Benton,Koichi Takahashi,Steve Kornblau,Rajyalakshmi Luthra,Rashmi Kanagal-Shamanna,L. Jeffrey Medeiros,Guillermo Garcia-Manero,Hagop M. Kantarjian,P. Andrew Futreal,Funda Meric-Bernstam,Keyur P. Patel +13 more
TL;DR: Careful annotation and review of NGS panels in patients with hematologic malignancies can provide a useful screening tool to systematically improve upon the detection of potentially pathogenic germline variants.
Journal Article
Mutation Analysis of the THRA1 Gene in Breast Cancer: Deletion/Fusion of the Gene to a Novel Sequence on 17q in the BT474 Cell Line
P. Andrew Futreal,Charles Cochran,Jeffrey R. Marks,J. Dirk Iglehart,Wolfgang Zimmerman,J. Carl Barrett,Roger W. Wiseman +6 more
TL;DR: All nine protein-encoding exons of THRA1 were examined for point mutations via single strand conformation analysis in a series of primary breast tumors, breast cancer cell lines, and lymphoblastoid cell lines derived from the youngest affected members of several German breast cancer families.
Journal ArticleDOI
Testing for hereditary breast and ovarian cancer in the southeastern United States.
Alexander Miron,Alexander Miron,Joellen M. Schildkraut,Barbara K. Rimer,Eric P. Winer,Celette Sugg Skinner,P. Andrew Futreal,Duane Culler,Brian Calingaert,Shelly Clark,P. Kelly Marcom,J. Dirk Iglehart,J. Dirk Iglehart +12 more
TL;DR: Characterization of mutations and uncharacterized variants in the breast cancer susceptibility genes BRCA1 and BRC a2, as observed in a population of breast cancer patients from the southeastern United States, and a preliminary look at how counseling and testing affected intentions toward prophylactic surgery are provided.