P
P. Andrew Futreal
Researcher at University of Texas at Austin
Publications - 32
Citations - 11582
P. Andrew Futreal is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Breast cancer & Tumor suppressor gene. The author has an hindex of 18, co-authored 32 publications receiving 10098 citations. Previous affiliations of P. Andrew Futreal include Howard Hughes Medical Institute & Wellcome Trust.
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Journal ArticleDOI
The driver landscape of sporadic chordoma.
Patrick S. Tarpey,Sam Behjati,Sam Behjati,Matthew D. Young,Inigo Martincorena,Ludmil B. Alexandrov,Sarah J. Farndon,Sarah J. Farndon,Charlotte Guzzo,Claire Hardy,Calli Latimer,Adam Butler,Jon W. Teague,Adam Shlien,P. Andrew Futreal,Sohrab P. Shah,Ali Bashashati,Farzad Jamshidi,Torsten O. Nielsen,David G. Huntsman,Daniel Baumhoer,Sebastian Brandner,Jay S. Wunder,Brendan C. Dickson,Patricia Cogswell,Josh Sommer,Joanna J. Phillips,M Fernanda Amary,Roberto Tirabosco,Nischalan Pillay,Nischalan Pillay,Stephen Yip,Michael R. Stratton,Adrienne M. Flanagan,Adrienne M. Flanagan,Peter J. Campbell,Peter J. Campbell +36 more
TL;DR: The somatic driver landscape of 104 cases of sporadic chordoma is defined, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations in LYST, a potential novel cancer gene in chordoma.
Journal ArticleDOI
Localization of the gene for distal hereditary motor neuronopathy VII (dHMN-VII) to chromosome 2q14.
Meriel McEntagart,N. Norton,Hywel Williams,M. Dawn Teare,Melanie Dunstan,Philip Baker,Henry Houlden,Mary M. Reilly,Nicholas W. Wood,Peter S. Harper,P. Andrew Futreal,Nigel Williams,Nazneen Rahman +12 more
TL;DR: A genomewide linkage search in a large Welsh pedigree with dHMN-VII was performed and linkage to chromosome 2q14 was established, confirming the location of the gene and providing evidence for a founder mutation segregating in both pedigrees.
Journal ArticleDOI
Managing hereditary ovarian cancer risk
TL;DR: The identification of the genes responsible for most hereditary ovarian cancers (BRCA1, BRCA2) means oophorectomy can be offered specifically to women who are mutation carriers, and noncarriers in these families can be reassured that their risk of ovarian cancer is not increased.
Journal ArticleDOI
K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary.
Angeles A. Alvarez,William F. Moore,Stanley J. Robboy,Rex C. Bentley,Curtis Gumbs,P. Andrew Futreal,Andrew Berchuck +6 more
TL;DR: The presence of identical K-ras mutations in some SBOT and their associated MIC suggests that they are related processes, which may arise due to a field effect, or alternatively some MIC may represent metastases from the primary ovarian tumor.
Journal ArticleDOI
Isolation of a diverged homeobox gene, M0X1, from the BRCA1 region on 17q21 by solution hybrid capture
P. Andrew Futreal,Charles Cochran,Judith Rosenthal,Judith Rosenthal,Yoshlo Miki,Jeff Swenson,Maurine Hobbs,Maurine Hobbs,Maurine Hobbs,L. Michelle Bennett,Astrid Haugen-Strano,Jeffrey R. Marks,Jeffrey R. Marks,J. Carl Barrett,Sean V. Tavtlglan,Sean V. Tavtlglan,Donna Shattuck-Eldens,Donna Shattuck-Eldens,Alexander Kamb,Alexander Kamb,Mark H. Skolnick,Mark H. Skolnick,Roger W. Wiseman +22 more
TL;DR: The widespread expression of MOX1 in non-embryonal tissues suggests a role in normal cell biology which warrants further study and represents an attractive candidate for the BRCA1 gene.