C
Charles Cochran
Researcher at National Institutes of Health
Publications - 19
Citations - 8777
Charles Cochran is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Loss of heterozygosity & Gene mapping. The author has an hindex of 16, co-authored 19 publications receiving 8500 citations.
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Journal ArticleDOI
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Yoshio Miki,Jeff Swensen,Donna M Shattuck-Eidens,P. Andrew Futreal,Keith D Harshman,Sean V. Tavtigian,Qingyun Liu,Charles Cochran,L. Michelle Bennett,Wei Ding,Russell Bell,Judith Rosenthal,Charles E. Hussey,Thanh Tran,Melody McClure,Cheryl Frye,Tom Hattier,Robert Phelps,Astrid Haugen-Strano,Harold Katcher,Kazuko Yakumo,Zahra Gholami,Daniel Shaffer,Steven Stone,Steven Bayer,Christian Wray,Robert Bogden,Priya Dayananth,John R. Ward,Patricia N. Tonin,Steven A. Narod,Pam K. Bristow,Frank H. Norris,Leah M. Helvering,Paul Morrison,Paul Robert Rosteck,Mei Lai,J. Carl Barrett,Cathryn M. Lewis,Susan L. Neuhausen,Lisa A. Cannon-Albright,David E. Goldgar,Roger W. Wiseman,Alexander Kamb,Mark H. Skolnick +44 more
TL;DR: A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
Journal ArticleDOI
BRCA1 mutations in primary breast and ovarian carcinomas
P. Andrew Futreal,Qingyun Liu,Donna M Shattuck-Eidens,Charles Cochran,Keith D Harshman,Sean V. Tavtigian,L. Michelle Bennett,Astrid Haugen-Strano,Jeff Swensen,Yoshio Miki,Ken Eddington,Melody McClure,Cheryl Frye,Jane Weaver-Feldhaus,Wei Ding,Zahra Gholami,Peter Söderkvist,Lori A. Terry,Suresh C. Jhanwar,Andrew Berchuck,J. Dirk Iglehart,Jeffrey R. Marks,Dennis G. Ballinger,J. Cari Barrett,Mark H. Skolnick,Mark H. Skolnick,Alexander Kamb,Roger W. Wiseman +27 more
TL;DR: Results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.
Journal ArticleDOI
BRCA2 mutations in primary breast and ovarian cancers
Johnathan M. Lancaster,Richard Wooster,Jonathon Mangion,Catherine M. Phelan,Catherine M. Phelan,Catherine M. Phelan,Charles Cochran,Curtis Gumbs,Sheila Seal,Rita Barfoot,N. Collins,Graham R. Bignell,Sandeep Patel,Rifat Hamoudi,Catharina Larsson,Roger W. Wiseman,Andrew Berchuck,J. Dirk Iglehart,Jeffrey R. Marks,Alan Ashworth,Michael R. Stratton,P. Andrew Futreal +21 more
TL;DR: The results suggest that BRCA2 is a very infrequent target for somatic inactivation in breast and ovarian carcinomas, similar to the results obtained torBRCAL.
Journal ArticleDOI
Mutation analysis of the BRCA2 gene in 49 site–specific breast cancer families
Catherine M. Phelan,Johnathan M. Lancaster,Patricia N. Tonin,Curtis Gumbs,Charles Cochran,Ronald F. Carter,Parviz Ghadirian,Chantal Perret,Roxana Moslehi,F. Dion,M C Faucher,K Dole,Sepideh Karimi,William D. Foulkes,H Lounis,Ellen Warner,Paul E. Goss,David E. Anderson,Catharina Larsson,Steven A. Narod,P. A. Futreal +20 more
TL;DR: The results suggest the possibilty that the proportion of site-specific breast cancer families attributable to BRCA2 may be overestimated.
Journal Article
Detection of Frequent Allelic Loss on Proximal Chromosome 17q in Sporadic Breast Carcinoma Using Microsatellite Length Polymorphisms
P. A. Futreal,P. Söderkvist,P. Söderkvist,P. Söderkvist,Jeffrey R. Marks,J. D. Iglehart,Charles Cochran,J C Barrett,Roger W. Wiseman +8 more
TL;DR: These markers have recently been localized to a 6-cM interval of proximal chromosome 17q in bands 17q11.2-q21 and map within the region of the early-onset familial breast cancer locus, implying that the same gene or genes may be involved in both sporadic and familial breast tumors.