P
Paolo Pelosi
Researcher at University of Genoa
Publications - 975
Citations - 47463
Paolo Pelosi is an academic researcher from University of Genoa. The author has contributed to research in topics: Mechanical ventilation & Lung injury. The author has an hindex of 93, co-authored 852 publications receiving 37918 citations. Previous affiliations of Paolo Pelosi include University of Insubria & Heidelberg University.
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Journal ArticleDOI
Intraoperative Ventilation Strategies to Reduce Pulmonary Complications in Obese Patients-Reply.
Journal ArticleDOI
An in-vitro study to evaluate high-volume low-pressure endotracheal tube cuff deflation dynamics.
Joan Martí,Gianluigi Li Bassi,Valentina Isetta,Miguel R Lazaro,Eli Aguilera-Xiol,Talitha Comaru,Denise Battaglini,Andrea Meli,Miguel Ferrer,Daniel Navajas,Paolo Pelosi,Davide Chiumello,Antoni Torres,Ramon Farré +13 more
TL;DR: In controlled in-vitro settings, ETT cuffs consistently deflate over time, and the cuff pilot balloon valve plays a central role in this occurrence.
Journal ArticleDOI
The effect of patient-ventilator asynchrony on lung and diaphragmatic injury in experimental acute respiratory distress syndrome: laboratory study.
Jakob Wittenstein,Robert Huhle,Mark Leiderman,Marius A Möbius,Anja Braune,S. Tauer,Paul Herzog,Giulio Barana,Alessandra de Ferrari,Andrea Corona,Thomas Bluth,Thomas Kiss,Andreas Güldner,Marcus J. Schultz,Patricia R. M. Rocco,Paolo Pelosi,Marcelo Gama de Abreu,Marcelo Gama de Abreu,Martin Scharffenberg +18 more
Abstract: BACKGROUND Patient-ventilator asynchrony during mechanical ventilation may exacerbate lung and diaphragm injury in spontaneously breathing subjects. We investigated whether subject-ventilator asynchrony increases lung and/or diaphragmatic injury in a porcine model of acute respiratory distress syndrome (ARDS). METHODS ARDS was induced in adult female pigs by lung lavage and injurious ventilation, before mechanical ventilation by pressure assist-control for 12h. Mechanically ventilated pigs were randomised to spontaneously breath with, or without, induced subject-ventilator asynchrony, or neuromuscular blockade (n=7/group). Subject-ventilator asynchrony was produced by ineffective, auto- or double-triggering of spontaneous breaths. The primary outcome was mean alveolar septal thickness (where thickening of the alveolar wall indicates worse lung injury). Secondary outcomes included distribution of ventilation (electrical impedance tomography), lung morphometric analysis, inflammatory biomarkers (gene expression), lung wet-to-dry ratio and diaphragmatic muscle fibre thickness. RESULTS Mean alveolar septal thickness was similar in pigs randomised to subject-ventilator asynchrony (mean (SD):29.5% (10.8) asynchronous breaths of total breaths; n=7) compared to synchronous spontaneous breathing (asynchronous breaths 1.8% (2.9) of total breaths; n=7). There was no difference in mean alveolar septal thickness throughout upper and lower lungs lobes between pigs randomised to subject-ventilator asynchrony versus synchronous spontaneous breathing (87.3-92.2μm after subject-ventilator asynchrony, compared to 84.1-95.0 μm in synchronised spontaneous breathing; P=0.956). There were also no differences between groups in wet-to-dry ratio, diaphragmatic muscle fibre thickness, atelectasis, lung aeration, and mRNA expression levels for inflammatory cytokines pivotal in ARDS pathogenesis. CONCLUSION Subject-ventilator asynchrony during spontaneous breathing did not exacerbate lung injury and dysfunction in experimental ARDS.
Journal ArticleDOI
Prevalence and clinical consequences of atelectasis in SARS-CoV-2 pneumonia: a computed tomography retrospective cohort study.
Álvaro Mingote,Andrea Albajar,Paulino García Benedito,Jessica Garcia-Suarez,Paolo Pelosi,Lorenzo Ball,Javier García-Fernández +6 more
TL;DR: In this article, the authors estimate the prevalence of atelectasis assessed with computer tomography (CT) in SARS-CoV-2 pneumonia and the relationship between the amount of at electasis with oxygenation impairment, Intensive Care Unit admission rate and the length of in-hospital stay.
Journal ArticleDOI
Restrictive versus Liberal Fluid Therapy for Post-Cesarean Acute Kidney Injury in Severe Preeclampsia: a Pilot Randomized Clinical Trial.
Wallace Andrino da Silva,Carlo Victor A Varela,Aline Macêdo Pinheiro,Paula Castro Scherer,Rossana Pulcineli Vieira Francisco,Marcelo Luis Abramides Torres,Maria José Carvalho Carmona,Fernando Bliacheriene,Lucia Andrade,Paolo Pelosi,Luiz Marcelo Sá Malbouisson +10 more
TL;DR: Among patients with severe preeclampsia, a restrictive fluid regimen during cesarean section was not associated with increased postoperative AKI.