P
Paolo Pelosi
Researcher at University of Genoa
Publications - 975
Citations - 47463
Paolo Pelosi is an academic researcher from University of Genoa. The author has contributed to research in topics: Mechanical ventilation & Lung injury. The author has an hindex of 93, co-authored 852 publications receiving 37918 citations. Previous affiliations of Paolo Pelosi include University of Insubria & Heidelberg University.
Papers
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Journal ArticleDOI
PEEP decreases atelectasis and extravascular lung water but not lung tissue volume in surfactant-washout lung injury
Thomas Luecke,Harry Roth,Peter Herrmann,Alf Joachim,Gerald Weisser,Paolo Pelosi,Michael Quintel +6 more
TL;DR: The main findings are that PEEP effectively decreases extravascular lung water (EVLW), making EVLW a valuable bedside parameter indicating alveolar recruitment, similar to measurements of transpulmonary shunt, and that excess tissue volume may not be suitable to reflect overall severity of lung disease.
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Combined use of serum (1,3)-β- d -glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units
Daniele Roberto Giacobbe,Malgorzata Mikulska,Mario Tumbarello,Elisa Furfaro,Marzia Spadaro,Angela Raffaella Losito,Alessio Mesini,Gennaro De Pascale,Anna Marchese,Marco Bruzzone,Paolo Pelosi,Michele Mussap,Alexandre Molin,Massimo Antonelli,Brunella Posteraro,Maurizio Sanguinetti,Claudio Viscoli,Valerio Del Bono +17 more
TL;DR: The combined use of PCT and BDG could be helpful in the diagnostic workflow for critically ill patients with suspected candidaemia.
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Prognostic role of clinical and laboratory criteria to identify early ventilator-associated pneumonia in brain injury.
Paolo Pelosi,Alessandra Barassi,Paolo Severgnini,Barbara Gomiero,Sergio Finazzi,Giampaolo Merlini,Gianvico Melzi d'Eril,Maurizio Chiaranda,Michael S. Niederman +8 more
TL;DR: In this article, the authors investigated the role of clinical pulmonary infection score (CPIS), serum levels of procalcitonin (PCT), C-reactive protein (CRP), and serum amyloid A (SAA) in the detection of patients with early ventilator-associated pneumonia (VAP).
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Recruitment maneuvers modulate epithelial and endothelial cell response according to acute lung injury etiology.
Pedro L. Silva,Lillian Moraes,Raquel S. Santos,Cynthia S. Samary,Maíra Ramos,Cintia L. Santos,Marcelo M. Morales,Vera Luiza Capelozzi,Cristiane S. N. B. Garcia,Marcelo Gama de Abreu,Paolo Pelosi,John J. Marini,Patricia R. M. Rocco +12 more
TL;DR: In both acute lung injury groups, recruitment maneuvers improved respiratory mechanics, but stepwise recruitment maneuver without sustained airway pressure appeared to associate with less biological impact on lungs.
Journal ArticleDOI
The extracellular matrix of the lung and its role in edema formation
TL;DR: Once conditions of increased microvascular filtration are established, matrix remodeling proceeds fairly rapidly due to the activation of proteases, and a massive matrix deposition of collagen fiber decreases interstitial compliance and therefore makes the tissue safety factor stronger.