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Patricia H. Alvarenga
Researcher at Federal University of Rio de Janeiro
Publications - 17
Citations - 654
Patricia H. Alvarenga is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 13 publications receiving 539 citations. Previous affiliations of Patricia H. Alvarenga include Johns Hopkins University & National Institutes of Health.
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Journal ArticleDOI
Aedes aegypti peritrophic matrix and its interaction with heme during blood digestion.
Valéria Páscoa,Pedro L. Oliveira,Marílvia Dansa-Petretski,José R. Silva,Patricia H. Alvarenga,Marcelo Jacobs-Lorena,Francisco J.A. Lemos +6 more
TL;DR: The data indicate that the peritrophic matrix of Aedes aegypti performs a central role in heme detoxification in this insect, suggesting the existence of specific binding sites for hemin in the PM.
Journal ArticleDOI
A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates
Fabiano Oliveira,Edgar Rowton,Hamide Aslan,Regis Gomes,Regis Gomes,Philip A. Castrovinci,Patricia H. Alvarenga,Maha Abdeladhim,Clarissa Teixeira,Clarissa Teixeira,Claudio Meneses,Lindsey T. Kleeman,Anderson B. Guimarães-Costa,Tobin Rowland,Dana C. Gilmore,Seydou Doumbia,Steven G. Reed,Phillip G. Lawyer,John F. Andersen,Shaden Kamhawi,Jesus G. Valenzuela +20 more
TL;DR: It is demonstrated that a vaccine against sand fly salivary protein can protect nonhuman primate from leishmania infection and PdSP15 sequence and structure show no homology to mammalian proteins, further demonstrating its potential as a component of a vaccine for human leishmaniasis.
Journal ArticleDOI
Identification of the Aedes aegypti peritrophic matrix protein AeIMUCI as a heme-binding protein.
Martin Devenport,Patricia H. Alvarenga,Li Shao,Hisashi Fujioka,M. Lucia Bianconi,Pedro L. Oliveira,Marcelo Jacobs-Lorena +6 more
TL;DR: It is shown that recombinant AeIMUC1 can bind large amounts of heme in vitro, suggesting for the first time a role for a PM protein in heme detoxification during blood digestion.
Journal ArticleDOI
Glucose metabolism during embryogenesis of the hard tick Boophilus microplus
Jorge Moraes,Antonio Galina,Patricia H. Alvarenga,Gustavo Lazzaro Rezende,Gustavo Lazzaro Rezende,Aoi Masuda,Itabajara da Silva Vaz,Carlos Logullo +7 more
TL;DR: G glycogen and glucose, formed during B. microplus embryogenesis after blastoderm formation, are produced by intense gluconeogenesis, as well as phosphoenolpyruvate carboxykinase activities after embryo cellularization.
Journal ArticleDOI
The Function and Three-Dimensional Structure of a Thromboxane A2/Cysteinyl Leukotriene-Binding Protein from the Saliva of a Mosquito Vector of the Malaria Parasite
Patricia H. Alvarenga,Patricia H. Alvarenga,Ivo M.B. Francischetti,Eric Calvo,Anderson Sá-Nunes,Anderson Sá-Nunes,José M. C. Ribeiro,John F. Andersen +7 more
TL;DR: A salivary protein from a malaria-transmitting mosquito uses a single domain to bind to thromboxane A2 and cysteinyl leukotrienes and prevent blood clotting and inflammation in the host on which it feeds.