C
Clarissa Teixeira
Researcher at Oswaldo Cruz Foundation
Publications - 48
Citations - 1988
Clarissa Teixeira is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Leishmania & Leishmania braziliensis. The author has an hindex of 24, co-authored 46 publications receiving 1813 citations. Previous affiliations of Clarissa Teixeira include Federal University of Bahia & National Institutes of Health.
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Journal ArticleDOI
Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model.
Regis Gomes,Regis Gomes,Clarissa Teixeira,Clarissa Teixeira,Maria Jânia Teixeira,Fabiano Oliveira,Fabiano Oliveira,Maria José Menezes,Claire Crola da Silva,Camila I. de Oliveira,José Carlos Miranda,Dia-Eldin A. Elnaiem,Shaden Kamhawi,Jesus G. Valenzuela,Cláudia Brodskyn +14 more
TL;DR: It is shown that immunity to a defined salivary protein (LJM19) confers powerful protection against the fatal outcome of a parasitic disease, which reinforces the concept of using components of arthropod saliva in vaccine strategies against vector-borne diseases.
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Sand Fly Salivary Proteins Induce Strong Cellular Immunity in a Natural Reservoir of Visceral Leishmaniasis with Adverse Consequences for Leishmania
Nicolas Collin,Regis Gomes,Clarissa Teixeira,Lily I. Cheng,Andre Laughinghouse,Jerrold M. Ward,Dia Eldin Elnaiem,Laurent Fischer,Jesus G. Valenzuela,Shaden Kamhawi +9 more
TL;DR: Certain sand fly salivary proteins are potent immunogens obligatorily co-deposited with Leishmania parasites during transmission and their inclusion in an anti-Leishmania vaccine would exploit anti-saliva immunity following an infective sand fly bite and set the stage for a protective anti- leishmania immune response.
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Chemokines in host–parasite interactions in leishmaniasis
Maria Jania Teixeira,Maria Jania Teixeira,Clarissa Teixeira,Clarissa Teixeira,Bruno B. Andrade,Bruno B. Andrade,Manoel Barral-Netto,Manoel Barral-Netto,Aldina Barral,Aldina Barral +9 more
TL;DR: Crucial to the defense against leishmaniasis is the ability of the host to mount a cell-mediated immune response capable of controlling and/or eliminating the parasite.
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A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates
Fabiano Oliveira,Edgar Rowton,Hamide Aslan,Regis Gomes,Regis Gomes,Philip A. Castrovinci,Patricia H. Alvarenga,Maha Abdeladhim,Clarissa Teixeira,Clarissa Teixeira,Claudio Meneses,Lindsey T. Kleeman,Anderson B. Guimarães-Costa,Tobin Rowland,Dana C. Gilmore,Seydou Doumbia,Steven G. Reed,Phillip G. Lawyer,John F. Andersen,Shaden Kamhawi,Jesus G. Valenzuela +20 more
TL;DR: It is demonstrated that a vaccine against sand fly salivary protein can protect nonhuman primate from leishmania infection and PdSP15 sequence and structure show no homology to mammalian proteins, further demonstrating its potential as a component of a vaccine for human leishmaniasis.
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The midgut transcriptome of Lutzomyia longipalpis: comparative analysis of cDNA libraries from sugar-fed, blood-fed, post-digested and Leishmania infantum chagasi-infected sand flies
Ryan C. Jochim,Ryan C. Jochim,Clarissa Teixeira,Andre Laughinghouse,Jianbing Mu,Fabiano Oliveira,Regis Gomes,Dia-Eldin A. Elnaiem,Jesus G. Valenzuela +8 more
TL;DR: This analysis suggests that Leishmania infantum chagasi alters the expression profile of certain midgut transcripts in the sand fly during blood meal digestion and that this modulation may be relevant for the survival and establishment of the parasite in the gut of the fly.