P
Patricia P. Garcez
Researcher at Federal University of Rio de Janeiro
Publications - 41
Citations - 2495
Patricia P. Garcez is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Zika virus & Microcephaly. The author has an hindex of 16, co-authored 35 publications receiving 1958 citations. Previous affiliations of Patricia P. Garcez include Francis Crick Institute & National Institute for Medical Research.
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Journal ArticleDOI
Zika virus impairs growth in human neurospheres and brain organoids
Patricia P. Garcez,Erick Correia Loiola,Rodrigo Madeiro da Costa,Luiza M. Higa,Pablo Trindade,Rodrigo Delvecchio,Juliana M. Nascimento,Rodrigo Brindeiro,Amilcar Tanuri,Stevens K. Rehen +9 more
TL;DR: Results suggest that ZIKV abrogates neurogenesis during human brain development when it targets human brain cells, reducing their viability and growth as neurospheres and brain organoids.
Journal ArticleDOI
MicroRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons
Federico Dajas-Bailador,Boyan B. Bonev,Patricia P. Garcez,Peter Stanley,François Guillemot,Nancy Papalopulu +5 more
TL;DR: It is proposed that miR-9 links regulatory signaling processes with dynamic translation mechanisms, controlling Map1b protein levels and axon development, and controlled axonal extension and branching by regulating the levels of Map1B, an important protein for microtubule stability.
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Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models
Rodrigo Delvecchio,Luisa M. Higa,Paula Pezzuto,Ana Luiza Chaves Valadão,Patricia P. Garcez,Fábio Luiz Monteiro,Erick Correia Loiola,André Alves Dias,Fabio J Moreira da Silva,Matthew T. Aliota,Elizabeth A. Caine,Jorge E. Osorio,Maria Bellio,David H. O’Connor,Stevens K. Rehen,Renato S. Aguiar,Andrea Savarino,Loraine Campanati,Amilcar Tanuri +18 more
TL;DR: It is demonstrated that chloroquine reduces the number of ZikV-infected cells in vitro, and inhibits virus production and cell death promoted by ZIKV infection without cytotoxic effects.
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New insights into the development of the human cerebral cortex
Zoltán Molnár,Gavin J. Clowry,Nenad Sestan,Ayman Alzu'bi,Trygve E. Bakken,Robert F. Hevner,Petra Susan Hüppi,Ivica Kostović,Pasko Rakic,Eva S. Anton,David Edwards,Patricia P. Garcez,Anna Hoerder-Suabedissen,Arnold R. Kriegstein +13 more
TL;DR: Recent studies are highlighted that address how differences emerge during development focusing on diverse facets of the authors' evolution, including perception, thought, language, attention, episodic memory and voluntary movement.
Journal ArticleDOI
Zika virus disrupts molecular fingerprinting of human neurospheres.
Patricia P. Garcez,Juliana M. Nascimento,Janaina Mota de Vasconcelos,Rodrigo Madeiro da Costa,Rodrigo Delvecchio,Pablo Trindade,Erick Correia Loiola,Luiza M. Higa,Juliana S. Cassoli,Gabriela Vitória,Patrícia Carvalho de Sequeira,Jaroslaw Sochacki,Renato S. Aguiar,Hellen Thais Fuzii,Ana Maria Bispo de Filippis,João Lídio da Silva Gonçalves Vianez Júnior,Amilcar Tanuri,Daniel Martins-de-Souza,Stevens K. Rehen +18 more
TL;DR: Altered alterations in human neurospheres derived from induced pluripotent stem cells infected with the strain of Zika virus that is circulating in Brazil are described and point to biological mechanisms implicated in brain malformations that can be exploited as therapeutic potential targets to mitigate it.