Ana Luiza Chaves Valadão

TL;DR: It is demonstrated that chloroquine reduces the number of ZikV-infected cells in vitro, and inhibits virus production and cell death promoted by ZIKV infection without cytotoxic effects.

TL;DR: It is suggested that emetine is able to penetrate in intact HIV particles, and bind and block reverse transcription reaction, suggesting that it can be used as anti-HIV microbicide, as well as as an antiviral agent against Human Immunodeficiency Virus.

TL;DR: The new findings that connect the inflammatory pathways to cellular stress sensors and the strategies of Flaviviridae members to counteract these cellular mechanisms and escape immune response are reviewed.

TL;DR: In this article , the authors identify the NLRP1 inflammasome as a sensor of SARS-CoV-2 infection in lung epithelia and demonstrate that 3CL proteases also inactivate the pyroptosis executioner Gasdermin D (GSDMD).

TL;DR: In this paper , the authors conducted a meta-analysis of CRISPR knockout (KO) screens, which showed a high level of cell-type specificity of the identified hits, highlighting the necessity of additional models to uncover the full landscape of host factors.