P
Patrick Mouchet
Publications - 8
Citations - 1038
Patrick Mouchet is an academic researcher. The author has contributed to research in topics: Alkyl & Peptide sequence. The author has an hindex of 3, co-authored 8 publications receiving 1036 citations.
Papers
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Journal ArticleDOI
A peptide mimetic of an anti-CD4 monoclonal antibody by rational design
Florence Casset,Florence Roux,Patrick Mouchet,Cédric Bès,Thierry Chardès,Claude Granier,Jean-Claude Mani,Martine Pugnière,Daniel Laune,Bernard Pau,Michel Kaczorek,Roger Lahana,Anthony R. Rees +12 more
TL;DR: Using peptide mapping to determine 'active' antigen recognition residues, molecular modeling, and a molecular dynamics trajectory analysis, a peptide mimic of an anti-CD4 antibody is developed, containing antigen contact residues from multiple CDRs.
Patent
Compounds, compositions and method for transporting cyclosporin molecules through the blood brain barrier
TL;DR: In this article, a compound comprising at least a cyclosporin molecule and a peptide vector capable of transporting such a molecule through the blood brain barrier was proposed for treating or preventing disease of the central nervous system.
Journal ArticleDOI
Regioselective synthesis of peptidic derivatives and glycolamidic esters of Methotrexate
TL;DR: In this article, a method for regioselective synthesis of Methotrexate peptidic conjugates is described, where the amide bond is obtained either in solution or by using a combined liquid and solid phase synthesis.
Patent
New cyclosporin derivatives, containing bonded peptide vector for crossing blood-brain barrier, used for treating cerebral disorders such as neurodegenerative diseases, cerebral trauma or cerebrovascular accidents
TL;DR: New cyclosporin compounds (I) comprise at least one peptide vector (III) capable of transporting (II) across the blood-brain barrier as mentioned in this paper, which is defined as a peptide that is capable of transferring (III).
Patent
Composes, compositions et methode pour le transport des molecules de cyclosporine a travers la barriere hemato-encephalique
TL;DR: In this paper, an invention concerne un compose qui comprend au moins une molecule de cyclosporine and a vecteur peptidique capable de transporter ladite molecule traversing the barriere hemato-encephalique.