Claude Granier

TL;DR: Using peptide mapping to determine 'active' antigen recognition residues, molecular modeling, and a molecular dynamics trajectory analysis, a peptide mimic of an anti-CD4 antibody is developed, containing antigen contact residues from multiple CDRs.

TL;DR: The binding of neurotensin to synaptic membranes from rat brain was studied at 24 degrees with the use of [3H]neurotensin and revealed that the addition of the residue arginine-8 to the neurotensIn-(9-13)-pentapeptide increases about 500-fold the relative binding potency, whereas the remaining portion of the NH2-terminal region is mainly responsible for full pharmacological potency.

TL;DR: A highly significant correlation was found between the two binding systems and the biological potencies obtained from the peptide abilities to contract isolated longitudinal smooth muscle strips of the guinea pig ileum when the binding affinities of neurotens in and neurotensin analogs were compared in the extraneural and neural systems.

TL;DR: The C-terminal peptide -Arg-Arg-Pro-Tyr-Ile-Leu fulfills all the structural requirements for mimicking the entire sequence, provided its α-amino end is protected by acetylation.

TL;DR: In this article, a specific monoclonal antibody (mAb Hinge76) was used to identify the cleavage site of proBNP1-108, an epitope present only in the precursor form.