Journal ArticleDOI
A peptide mimetic of an anti-CD4 monoclonal antibody by rational design
Florence Casset,Florence Roux,Patrick Mouchet,Cédric Bès,Thierry Chardès,Claude Granier,Jean-Claude Mani,Martine Pugnière,Daniel Laune,Bernard Pau,Michel Kaczorek,Roger Lahana,Anthony R. Rees +12 more
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TLDR
Using peptide mapping to determine 'active' antigen recognition residues, molecular modeling, and a molecular dynamics trajectory analysis, a peptide mimic of an anti-CD4 antibody is developed, containing antigen contact residues from multiple CDRs.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2003-07-18. It has received 1016 citations till now. The article focuses on the topics: Antibody mimetic & Peptide sequence.read more
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Dual variable domain immunoglobulins and uses thereof
TL;DR: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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Compositions and methods for treating and diagnosing cancer
TL;DR: In this article, the authors presented gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, and treatment of the stem cells.
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Binding domain-immunoglobulin fusion proteins
TL;DR: In this paper, binding domain-immunoglobulin fusion proteins are defined as proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, and can be recombinantly produced at high expression levels.
Patent
IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME
TL;DR: In this article, a variant Fc region comprising at least one amino acid modification relative to a wild-type Fc regions was proposed, which was used for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function mediated by FcγR is desired.
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Survey of the year 2003 commercial optical biosensor literature
Rebecca L. Rich,David G. Myszka +1 more
TL;DR: In this overview, 13 papers that should be on everyone's ‘must read’ list for 2003 are spotlighted and examples of how to identify and interpret high‐quality biosensor data are provided.
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Journal ArticleDOI
Beitrag zur kollektiven behandlung pharmakologischer reihenversuche
TL;DR: In this paper, ein Verfahren zur kollektiven behandlung von Reihenversuchen angegeben, das gestattet, bei kleinerem Umfang des Kollektivs (Reihenversuch mit vier bis funf Gruppen zu je sechs Tieren) and bei starker Streuung zu einem zahlenmasigen Ausdruck des Versuchsergebnisses zu gelangen.
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Prediction of the folding of short polypeptide segments by uniform conformational sampling.
TL;DR: A procedure, CONGEN, for uniformly sampling the conformational space of short polypeptide segments in proteins has been implemented and is generally capable of generating conformations where the lowest energy conformation matches the known structure within a rms deviation of 1 Å.
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A Chemical Approach to Protein Design—Template‐Assembled Synthetic Proteins (TASP)
TL;DR: A new approach is presented, developed in the laboratory, which opens a chemical route to artificial proteins with predetermined three-dimensional structures, allowing a first step towards the synthesis of new proteins with functional properties.
Journal ArticleDOI
Design, synthesis, and application of a Protein A mimetic
TL;DR: A nonpeptidyl mimic for Staphylococcus aureus Protein A (SpA) is developed that binds IgG competitively with SpA in solution and when immobilized on agarose beads, with an affinity constant of 105-106 M−1.
Journal ArticleDOI
Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo.
Byeong Woo Park,Hongtao Zhang,Chuan-Jin Wu,Alan Berezov,Xin Zhang,Raj Dua,Qiang Wang,Gary D. Kao,Donald M. O'Rourke,Mark I. Greene,Ramachandran Murali +10 more
TL;DR: A structure-based derivation of the AHNP represents a novel strategy for the design of receptor-specific tumor therapies for p185HER2/neu-expressing human cancers.