F
Florence Roux
Publications - 3
Citations - 1022
Florence Roux is an academic researcher. The author has contributed to research in topics: Peptide sequence & Antibody mimetic. The author has an hindex of 2, co-authored 3 publications receiving 1020 citations.
Papers
More filters
Journal ArticleDOI
A peptide mimetic of an anti-CD4 monoclonal antibody by rational design
Florence Casset,Florence Roux,Patrick Mouchet,Cédric Bès,Thierry Chardès,Claude Granier,Jean-Claude Mani,Martine Pugnière,Daniel Laune,Bernard Pau,Michel Kaczorek,Roger Lahana,Anthony R. Rees +12 more
TL;DR: Using peptide mapping to determine 'active' antigen recognition residues, molecular modeling, and a molecular dynamics trajectory analysis, a peptide mimic of an anti-CD4 antibody is developed, containing antigen contact residues from multiple CDRs.
Patent
Computational design methods for making molecular mimetics
TL;DR: In this article, the authors proposed methods for the design and synthesis of a molecule which mimics the activity of a parent molecule using a molecular dynamics simulation of the mimetic, and screening potential mimetics using molecular dynamics simulations.
Journal ArticleDOI
Les nouveaux inhibiteurs des métalloprotéinases à zinc
TL;DR: In this article, les metalloproteinases a zinc sont, aujourd'hui, considerees comme des cibles therapeutiques de premiare importance.