Cédric Bès

TL;DR: Using peptide mapping to determine 'active' antigen recognition residues, molecular modeling, and a molecular dynamics trajectory analysis, a peptide mimic of an anti-CD4 antibody is developed, containing antigen contact residues from multiple CDRs.

TL;DR: The Spot method was used to identify peptides from the variable parts of anti-hapten, anti-peptide and anti-protein antibodies that retain their specific antigen-binding capacity in the Spot format to map precisely key residues from the antibody paratope.

TL;DR: There is only limited amino acid replacement in most of the TPO-specific light chains, particularly in those encoded by J proximal IGLV or IGKV genes, suggesting that a defect in receptor editing can occur during aAb generation in AITD.

TL;DR: The results indicate that the information gained from a systematic exploration of the antigen binding capacity of synthetic peptides from immunoglobulin variable sequences can lead to the identification of bioactive paratope-derived peptides of potential pharmacological interest.

TL;DR: Identification of the discontinuous immunodominant region (IDR) could lead to improved diagnosis of thyroid autoimmune diseases by engineering “mini-TPO” as a target autoantigen or designing therapeutic peptides able to block undesired autoimmune responses.