M
Martine Pugnière
Researcher at University of Montpellier
Publications - 95
Citations - 4136
Martine Pugnière is an academic researcher from University of Montpellier. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 29, co-authored 89 publications receiving 3764 citations. Previous affiliations of Martine Pugnière include University of Barcelona & Centre national de la recherche scientifique.
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Journal ArticleDOI
A peptide mimetic of an anti-CD4 monoclonal antibody by rational design
Florence Casset,Florence Roux,Patrick Mouchet,Cédric Bès,Thierry Chardès,Claude Granier,Jean-Claude Mani,Martine Pugnière,Daniel Laune,Bernard Pau,Michel Kaczorek,Roger Lahana,Anthony R. Rees +12 more
TL;DR: Using peptide mapping to determine 'active' antigen recognition residues, molecular modeling, and a molecular dynamics trajectory analysis, a peptide mimic of an anti-CD4 antibody is developed, containing antigen contact residues from multiple CDRs.
Journal ArticleDOI
Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes
Loïc Martin,Francois Stricher,Dorothée Missé,Francesca Sironi,Martine Pugnière,Philippe Barthe,Rafael Prado-Gotor,Isabelle Freulon,Xavier Magne,Christian Roumestand,André Ménez,Paolo Lusso,Francisco Veas,Claudio Vita +13 more
TL;DR: A 27-amino acid CD4 mimic, CD4M33, is designed that presents optimal interactions with gp120 and binds to viral particles and diverse HIV-1 envelopes with CD4-like affinity and possesses functional properties of CD4, including the ability to unmask conserved neutralization epitopes of gp120 that are cryptic on the unbound glycoprotein.
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Phosphatidylinositol‐(4,5)‐bisphosphate enables efficient secretion of HIV‐1 Tat by infected T‐cells
Fabienne Rayne,Solène Debaisieux,Hocine Yezid,Yea-Lih Lin,Clément Mettling,Karidia Konate,Nathalie Chazal,Stefan T. Arold,Martine Pugnière,Françoise Sanchez,Anne Bonhoure,Laurence Briant,Erwann P. Loret,Christian Roy,Bruno Beaumelle +14 more
TL;DR: It is shown that, in HIV‐1‐infected primary CD4+ T‐cells that are the main targets of the virus, Tat accumulates at the plasma membrane because of its specific binding to phosphatidylinositol‐4,5‐bisphosphate (PI( 4,5)P2).
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Insight into Invertebrate Defensin Mechanism of Action: OYSTER DEFENSINS INHIBIT PEPTIDOGLYCAN BIOSYNTHESIS BY BINDING TO LIPID II*
Paulina Schmitt,Miriam Wilmes,Martine Pugnière,André Aumelas,Evelyne Bachère,Evelyne Bachère,Hans-Georg Sahl,Tanja Schneider,Delphine Destoumieux-Garzón,Delphine Destoumieux-Garzón +9 more
TL;DR: It is proposed that oyster defensin activity results from selective forces that have conserved residues involved in lipid II binding and diversified residues at the surface of oysterdefensins that could improve electrostatic interactions with the bacterial membranes.
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Evidence of a bactericidal permeability increasing protein in an invertebrate, the Crassostrea gigas Cg-BPI.
Marcelo Gonzalez,Yannick Gueguen,Delphine Destoumieux-Garzón,Bernard Romestand,Julie Fievet,Martine Pugnière,Françoise Roquet,Jean-Michel Escoubas,Franck Vandenbulcke,Ofer Levy,Laure Sauné,Philippe Bulet,Evelyne Bachère +12 more
TL;DR: A cDNA sequence with homologies to members of the LPS-binding protein and bactericidal/permeability-increasing protein (BPI) family was identified in the oyster Crassostrea gigas, the first characterization of a BPI in an invertebrate.