P
Patrick S. G. Chain
Researcher at Los Alamos National Laboratory
Publications - 321
Citations - 38829
Patrick S. G. Chain is an academic researcher from Los Alamos National Laboratory. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 65, co-authored 301 publications receiving 34601 citations. Previous affiliations of Patrick S. G. Chain include McMaster University & Joint Genome Institute.
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Journal ArticleDOI
Complete Genome Sequence of Yersinia pestis Strains Antiqua and Nepal516: Evidence of Gene Reduction in an Emerging Pathogen
Patrick S. G. Chain,Patrick S. G. Chain,Ping Hu,Stephanie Malfatti,Stephanie Malfatti,Lyndsay Radnedge,Frank W. Larimer,Frank W. Larimer,Lisa M. Vergez,Lisa M. Vergez,Patricia L. Worsham,May C. Chu,Gary L. Andersen +12 more
TL;DR: In this paper, the genomes of two isolates of the "classical" antiqua biovar, strains Antiqua and Nepal516, were compared with the corresponding features in Yersinia pseudotuberculosis, and the results showed that grouping Y. pestis strains based strictly on the classical definition of biovars does not accurately reflect the phylogenetic relationships within this species.
Journal ArticleDOI
Standards for Sequencing Viral Genomes in the Era of High-Throughput Sequencing
Jason T. Ladner,Brett Beitzel,Patrick S. G. Chain,Matthew G Davenport,Eric F. Donaldson,Matthew B. Frieman,Jeffrey R. Kugelman,Jens H. Kuhn,Jules O'Rear,Pardis C. Sabeti,Pardis C. Sabeti,David E. Wentworth,Michael R. Wiley,Guo-Yun Yu,Shanmuga Sozhamannan,Christopher E. Bradburne,Gustavo Palacios +16 more
TL;DR: This work proposes five “standard” categories that encompass all stages of viral genome finishing, and they are defined using simple criteria that are agnostic to the technology used for sequencing.
Journal Article
Complete Genome Sequence of Yersinia pestis Strains Antiqua and Nepal516: Evidence of Gene Reduction in an Emerging Pathogen
Patrick S. G. Chain,Ping Hu,Stephanie Malfatti,Lyndsay Radnedge,Frank W. Larimer,Lisa M. Vergez,Patricia L. Worsham,May C. Chu,Gary L. Andersen +8 more
TL;DR: The results presented here clearly demonstrate the differences between the two biovar antiqua lineages and support the notion that grouping Y. pestis strains based strictly on the classical definition of biovars does not accurately reflect the phylogenetic relationships within this species.
Journal ArticleDOI
Whole-Genome-Based Phylogeny and Divergence of the Genus Brucella
Jeffrey T. Foster,Stephen M. Beckstrom-Sternberg,Stephen M. Beckstrom-Sternberg,Talima Pearson,James S. Beckstrom-Sternberg,Patrick S. G. Chain,Patrick S. G. Chain,Patrick S. G. Chain,Francisco F. Roberto,Jonathan Hnath,Thomas Brettin,Paul Keim +11 more
TL;DR: A phylogeny using single nucleotide polymorphisms from 13 genomes and rooted the tree using the closely related soil bacterium and opportunistic human pathogen, Ochrobactrum anthropi suggests that most Brucella species diverged from their common B. ovis ancestor in the past 86,000 to 296,000 years, which precedes the domestication of their livestock hosts.
Journal ArticleDOI
Whole-Genome Analysis of the Methyl tert-Butyl Ether-Degrading Beta-Proteobacterium Methylibium petroleiphilum PM1
Staci R. Kane,Anu Chakicherla,Patrick S. G. Chain,Patrick S. G. Chain,Radomir Schmidt,Maria W. Shin,Tina C. Legler,Kate M. Scow,Frank W. Larimer,Frank W. Larimer,Susan Lucas,Paul G. Richardson,Krassimira R. Hristova +12 more
TL;DR: A recent whole-genome analysis of PM1 revealed an approximately 4-Mb circular chromosome and an approximately 600-kb megaplasmid, containing 3,831 and 646 genes, respectively as discussed by the authors.