P
Patrick T. Caswell
Researcher at Wellcome Trust Centre for Cell-Matrix Research
Publications - 56
Citations - 6061
Patrick T. Caswell is an academic researcher from Wellcome Trust Centre for Cell-Matrix Research. The author has contributed to research in topics: Integrin & Cell migration. The author has an hindex of 31, co-authored 49 publications receiving 5438 citations. Previous affiliations of Patrick T. Caswell include University of Glasgow & University of Leicester.
Papers
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Journal ArticleDOI
Mutant p53 Drives Invasion by Promoting Integrin Recycling
Patricia A.J. Muller,Patrick T. Caswell,Brendan Doyle,Marcin P. Iwanicki,Ee H. Tan,Saadia A. Karim,Natalia Lukashchuk,David A. F. Gillespie,Robert L. Ludwig,Pauline Gosselin,Anne Cromer,Joan S. Brugge,Owen J. Sansom,Jim C. Norman,Karen H. Vousden +14 more
TL;DR: It is shown that Mutant p53 expression can promote invasion, loss of directionality of migration, and metastatic behavior, and the possibility that blocking alpha5/beta1-integrin and/or the EGF receptor will have therapeutic benefit in mutant p53-expressing cancers is opened.
Journal ArticleDOI
Integrins: masters and slaves of endocytic transport.
TL;DR: New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration and can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis.
Journal ArticleDOI
Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments
Patrick T. Caswell,May T Chan,Andrew J. Lindsay,Mary W. McCaffrey,David Boettiger,Jim C. Norman +5 more
TL;DR: It is concluded that RCP provides a scaffold that promotes the physical association and coordinate trafficking of α5β1 and EGFR1 and that this drives migration of tumor cells into three-dimensional matrices.
Journal ArticleDOI
Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments
Patrick T. Caswell,Heather J. Spence,Maddy Parsons,Dominic P. White,Katherine Clark,Kwai Wa Cheng,Gordon B. Mills,Martin J. Humphries,Anthea J. Messent,Kurt I. Anderson,Mary W. McCaffrey,Bradford W. Ozanne,Jim C. Norman +12 more
TL;DR: Data indicate that Rab25 contributes to tumor progression by directing the localization of integrin-recycling vesicles and thereby enhancing the ability of tumor cells to invade the extracellular matrix.
Journal ArticleDOI
Integrin trafficking and the control of cell migration.
Patrick T. Caswell,Jim C. Norman +1 more
TL;DR: The findings of studies revealing the molecular mechanisms controlling integrin traffic are summarized, particularly those providing indications as to how these processes contribute to cell migration and tumour cell invasiveness.