P
Patrizia Porcu
Researcher at National Research Council
Publications - 58
Citations - 2647
Patrizia Porcu is an academic researcher from National Research Council. The author has contributed to research in topics: Neuroactive steroid & Allopregnanolone. The author has an hindex of 25, co-authored 54 publications receiving 2298 citations. Previous affiliations of Patrizia Porcu include University of California, San Diego & Oregon National Primate Research Center.
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Journal ArticleDOI
Role of brain allopregnanolone in the plasticity of gamma -aminobutyric acid type a receptor in rat brain during pregnancy and after delivery
Alessandra Concas,Maria Cristina Mostallino,Patrizia Porcu,Paolo Follesa,Maria Luisa Barbaccia,Marco Trabucchi,Robert H. Purdy,P. Grisenti,Giovanni Biggio +8 more
TL;DR: The results indicate that the plasticity of GABAA receptors during pregnancy and after delivery is functionally related to fluctuations in endogenous brain concentrations of AP whose rate of synthesis/metabolism appears to differ in the brain, compared with plasma, in pregnant rats.
Journal ArticleDOI
The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress.
Sandeep Kumar,Patrizia Porcu,David F. Werner,Douglas B. Matthews,Jaime L. Diaz-Granados,Rebecca S. Helfand,A. Leslie Morrow +6 more
TL;DR: The elucidation of the mechanisms that underlie adaptations to ethanol exposure are leading to a better understanding of the regulation of inhibitory transmission and new targets for therapies to support recovery from ethanol withdrawal and alcoholism.
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Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
Christine E. Marx,Christine E. Marx,Richard S.E. Keefe,Robert W. Buchanan,Robert M. Hamer,Jason D. Kilts,Jason D. Kilts,Daniel W. Bradford,Daniel W. Bradford,Jennifer L. Strauss,Jennifer L. Strauss,Jennifer C. Naylor,Jennifer C. Naylor,Victoria M. Payne,Victoria M. Payne,Jeffrey A. Lieberman,Adam Savitz,Linda A. Leimone,Lawrence A. Dunn,Lawrence A. Dunn,Patrizia Porcu,A. Leslie Morrow,Lawrence J. Shampine,Lawrence J. Shampine +23 more
TL;DR: Pregnenolone may be a promising therapeutic agent for negative symptoms in patients with schizophrenia or schizoaffective disorder receiving stable doses of second-generation antipsychotics and merits further investigation for cognitive symptoms in schizophrenia.
Journal ArticleDOI
Neurosteroidogenesis today: Novel targets for neuroactive steroid synthesis and action and their relevance for translational research.
Patrizia Porcu,Anna M. Barron,Cheryl A. Frye,Cheryl A. Frye,Alicia A. Walf,Alicia A. Walf,Alicia A. Walf,S.-Y. Yang,X.-Y. He,A. L. Morrow,Giancarlo Panzica,Roberto Cosimo Melcangi +11 more
TL;DR: This review summarises recent approaches that target the neuroactive steroid biosynthetic pathway at different levels aiming to promote neurosteroidogenesis, which may be beneficial not only for neurodegenerative diseases, such as Alzheimer's disease and age‐related dementia, but also for neuropsychiatric diseases, including alcohol use disorders.
Journal ArticleDOI
Changes in GABAA receptor γ2 subunit gene expression induced by long-term administration of oral contraceptives in rats
Paolo Follesa,Patrizia Porcu,Cristiana Sogliano,M Cinus,Francesca Biggio,Luisa Mancuso,Mc Mostallino,Anna Maria Paoletti,Rh Purdy,Giovanni Biggio,Alessandra Concas +10 more
TL;DR: Results indicate that long-term treatment with OCs induced a persistent reduction in the concentrations of pregnenolone, progesterone and its GABA(A) receptor-active metabolite, allopregnanolones, both in rats and women.