D
Douglas B. Matthews
Researcher at University of Wisconsin–Eau Claire
Publications - 81
Citations - 5009
Douglas B. Matthews is an academic researcher from University of Wisconsin–Eau Claire. The author has contributed to research in topics: Morris water navigation task & Hippocampal formation. The author has an hindex of 35, co-authored 76 publications receiving 4694 citations. Previous affiliations of Douglas B. Matthews include University of Memphis & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
The role of GABA(A) receptors in the acute and chronic effects of ethanol.
TL;DR: It is proposed that alterations in native GABAA receptor subunit assembly could alter the functional properties of these receptors, and post-translational modifications or other post-synaptic mechanisms may also explain changes in GAB AA receptor function.
Journal ArticleDOI
The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress.
Sandeep Kumar,Patrizia Porcu,David F. Werner,Douglas B. Matthews,Jaime L. Diaz-Granados,Rebecca S. Helfand,A. Leslie Morrow +6 more
TL;DR: The elucidation of the mechanisms that underlie adaptations to ethanol exposure are leading to a better understanding of the regulation of inhibitory transmission and new targets for therapies to support recovery from ethanol withdrawal and alcoholism.
Journal ArticleDOI
The nature and identification of quantitative trait loci: a community's view.
Oduola Abiola,Joe M. Angel,Philip Avner,Alexander A. Bachmanov,John K. Belknap,Beth Bennett,Elizabeth P. Blankenhorn,David A. Blizard,Valerie J. Bolivar,Gudrun A. Brockmann,Kari J. Buck,Jean Francois Bureau,William L. Casley,Elissa J. Chesler,James M. Cheverud,Gary A. Churchill,Melloni N. Cook,John C. Crabbe,Wim E. Crusio,Ariel Darvasi,Gerald de Haan,Peter Demant,Rebecca W. Doerge,Rosemary W. Elliott,Charles R. Farber,Lorraine Flaherty,Jonathan Flint,Howard K. Gershenfeld,John P. Gibson,Jing Gu,Weikuan Gu,Heinz Himmelbauer,Robert Hitzemann,Hui-Chen Hsu,Kent W. Hunter,Fuad A. Iraqi,Ritsert C. Jansen,Thomas E. Johnson,Byron C. Jones,Gerd Kempermann,Frank Lammert,Lu Lu,Kenneth F. Manly,Douglas B. Matthews,Juan F. Medrano,Margarete Mehrabian,Guy Mittleman,Beverly A. Mock,Jeffrey S. Mogil,Xavier Montagutelli,Grant Morahan,John D. Mountz,Hiroki Nagase,Richard S. Nowakowski,Bruce F. O'Hara,Alexander V. Osadchuk,Beverly Paigen,Abraham A. Palmer,Jeremy L. Peirce,Daniel Pomp,Michael Rosemann,Glenn D. Rosen,Leonard C. Schalkwyk,Ze'ev Seltzer,Stephen H. Settle,Kazuhiro Shimomura,Siming Shou,James M. Sikela,Linda D. Siracusa,Jimmy L. Spearow,Cory Teuscher,David W. Threadgill,Linda A. Toth,A. A. Toye,Csaba Vadasz,Gary Van Zant,Edward K. Wakeland,Robert W. Williams,Huang-Ge Zhang,Fei Zou +79 more
TL;DR: This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits.
Journal ArticleDOI
Neuroactive Steroid 3α-Hydroxy-5α-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol
Margaret J. VanDoren,Douglas B. Matthews,Gregory C. Janis,A. Chistina Grobin,Leslie L. Devaud,A. Leslie Morrow +5 more
TL;DR: Elevation of 3α,5α-THP levels by acute ethanol administration represents a novel mechanism of ethanol action as well as an important modulatory role for neurosteroids in the CNS.
Journal ArticleDOI
The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence.
TL;DR: It is suggested that 3alpha,5alpha-TH PROG and 3 alpha,5 alpha-TH DOC contribute to ethanol action and this interaction may represent a new mechanism of ethanol action.