Annette Lake

TL;DR: The role of the major histocompatibility complex in disease etiology is confirmed by revealing a strong human leukocyte antigen (HLA) association and new insight is provided into the pathogenesis of cHL.

TL;DR: Results are consistent with the notion that DNA from Reed‐Sternberg cells is present in the serum of HD patients, and further suggest that serum EBV should be evaluated as a prognostic marker.

TL;DR: There is strong evidence that EBV status is an etiologically important classification of cHL and also suggest that some components of the pathological process are common to both EBV-positive andEBV-negative patients.

TL;DR: The results of this study indicate that HLA class I polymorphisms may predispose patients to development of IM upon primary EBV infection, suggesting that genetic variation in T cell responses can influence the nature of primaryEBV infection and the level of viral persistence.

TL;DR: The findings suggest that HLA class I-restricted EBV-specific cytotoxic T-cell responses and events in the early immune response to EBV infection in IM play critical roles in the pathogenesis ofEBV-related HL.