F
Francisco J. Salguero
Researcher at Public Health England
Publications - 199
Citations - 5496
Francisco J. Salguero is an academic researcher from Public Health England. The author has contributed to research in topics: Virus & Medicine. The author has an hindex of 36, co-authored 171 publications receiving 4137 citations. Previous affiliations of Francisco J. Salguero include University of Surrey & University of Concepción.
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Journal ArticleDOI
Animal models for COVID-19.
César Muñoz-Fontela,William E. Dowling,Simon G. P. Funnell,Pierre Stéphane Gsell,A. Ximena Riveros-Balta,Randy A. Albrecht,Hanne Leth Andersen,Ralph S. Baric,Miles W. Carroll,Marco Cavaleri,Chuan Qin,Ian Crozier,Kai Dallmeier,Leon de Waal,Emmie de Wit,Leen Delang,Erik D. Dohm,W. Paul Duprex,Darryl Falzarano,Courtney L. Finch,Matthew B. Frieman,Barney S. Graham,Lisa E. Gralinski,Kate Guilfoyle,Bart L. Haagmans,Geraldine A. Hamilton,Amy L. Hartman,Sander Herfst,Suzanne J.F. Kaptein,William B. Klimstra,Ivana Knezevic,Philip R. Krause,Jens H. Kuhn,Roger Le Grand,Mark G. Lewis,Wen-Chun Liu,Pauline Maisonnasse,Anita K. McElroy,Vincent J. Munster,Nadia Oreshkova,Angela L. Rasmussen,Joana Rocha-Pereira,Barry Rockx,Estefanía Rodríguez,Thomas F. Rogers,Francisco J. Salguero,Michael Schotsaert,Koert J. Stittelaar,Hendrik Jan Thibaut,Chien Te K. Tseng,Júlia Vergara-Alert,Martin Beer,Trevor Brasel,Jasper Fuk-Woo Chan,Adolfo García-Sastre,Johan Neyts,Stanley Perlman,Douglas S. Reed,Juergen A. Richt,Chad J. Roy,Joaquim Segalés,Seshadri S. Vasan,Seshadri S. Vasan,Ana Maria Henao-Restrepo,Dan H. Barouch +64 more
TL;DR: The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.
Journal ArticleDOI
Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity.
Kathryn A. Ryan,Kevin R. Bewley,Susan A. Fotheringham,Gillian S. Slack,Phillip Brown,Yper Hall,Nadina Wand,Anthony C. Marriott,Breeze E. Cavell,Julia A. Tree,Lauren Allen,Marilyn Aram,Thomas Bean,Emily Brunt,Karen R. Buttigieg,Daniel P. Carter,Rebecca Cobb,Naomi Coombes,Steve J. Findlay-Wilson,Kerry J Godwin,Karen E. Gooch,Jade Gouriet,Rachel Halkerston,Debbie J Harris,Thomas Hender,Holly E. Humphries,Laura Hunter,Catherine M K Ho,Chelsea L Kennard,Stephanie Leung,Stephanie Longet,Didier Ngabo,Karen L. Osman,Jemma Paterson,Elizabeth J Penn,Steven T. Pullan,Emma Rayner,Oliver Skinner,Kimberley Steeds,Irene Taylor,Tom Tipton,Stephen Thomas,Carrie Turner,Robert J. Watson,Nathan R Wiblin,Sue Charlton,Bassam Hallis,Julian A. Hiscox,Simon G. P. Funnell,Mike Dennis,Catherine J. Whittaker,Michael G Catton,Julian Druce,Francisco J. Salguero,Miles W. Carroll,Miles W. Carroll +55 more
TL;DR: Characterise optimal infection dosage inducing upper respiratory tract (UTR) viral shedding, progression time of viral shed, and pathology in ferrets and finally provide evidence for protection after re-challenge in ferret model of SARS-CoV-2.
Journal ArticleDOI
Early detection of PrPres in BSE-infected bovine PrP transgenic mice.
Joaquín Castilla,A Gutiérrez Adán,Alejandro Brun,Belén Pintado,Miguel Ángel Ramírez,B. Parra,D. Doyle,Mark Rogers,Francisco J. Salguero,Carlos M. Sánchez,José Manuel Sánchez-Vizcaíno,Juan María Torres +11 more
TL;DR: The result indicates that prion infectivity in experimental mouse bioassays can be measured earlier by assessing immunologically the presence of PrPres in brains from inoculated animals.
Journal ArticleDOI
Cytokine Expression by Macrophages in the Lung of Pigs Infected with the Porcine Reproductive and Respiratory Syndrome Virus
Jaime Gómez-Laguna,Francisco J. Salguero,I. Barranco,F.J. Pallarés,Irene M. Rodríguez-Gómez,Antonio Bernabé,Librado Carrasco +6 more
TL;DR: It is suggested that PRRSV modulates the immune response by the up-regulation of IL-10, which may in turn reduce expression of cytokines involved in viral clearance (e.g.IFN-α, IFN-γ, IL-12p40 and TNF-α).
Journal ArticleDOI
A mixture containing galactooligosaccharide, produced by the enzymic activity of Bifidobacterium bifidum, reduces Salmonella enterica serovar Typhimurium infection in mice.
Laura E. J. Searle,Angus I. Best,Alejandro Núñez,Francisco J. Salguero,Linda K. Johnson,Ute Weyer,Alexandra H A Dugdale,W. A. Cooley,Ben Carter,Gareth Jones,George Tzortzis,Martin J. Woodward,Roberto M. La Ragione +12 more
TL;DR: Results indicate that Bimuno significantly reduced the colonization and pathology associated with S. Typhimurium infection in a murine model system, possibly by reducing the invasion of the pathogen into host cells.