Paul G. Pavicic

TL;DR: Cell culture studies from multiple laboratories demonstrate that macrophages developed in the presence of GM-CSF exhibit amplified response to M1 polarizing stimuli while M- CSF potentiates responses to M2 stimuli, suggesting these factors can be important determinants of the magnitude and duration of both acute and chronic inflammatory pathology.

TL;DR: Anti-CXCR2 and anti-PD1 synergized to reduce tumor weight and enhanced CD4+ and CD8+ T-cell infiltration in a Renca murine model, suggesting that CX CR2+ PMN-MDSC are important in reducing activity of anti- PD1 antibody.

TL;DR: A critical role is revealed for IL-1β produced by a TH17 cell–intrinsic ASC–NLRP3–caspase-8 inflammasome during inflammation of the central nervous system.

TL;DR: It is demonstrated that TTP is the predominant regulator of KC mRNA decay in mononuclear phagocytes acting via multiple 3′-untranslated region-localized AREs.

TL;DR: It is suggested that IL-17–mediated chemokine mRNA stabilization in nonmyeloid cells uses a mechanism that is distinct from that operating to control AU-rich mRNA stability in myeloids cells.