Z
Zizhen Kang
Researcher at Shanghai Jiao Tong University
Publications - 41
Citations - 2023
Zizhen Kang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Inflammation & Interleukin 17. The author has an hindex of 21, co-authored 37 publications receiving 1615 citations. Previous affiliations of Zizhen Kang include Cleveland Clinic & South Central University for Nationalities.
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Journal ArticleDOI
Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis
Zizhen Kang,Cengiz Z. Altuntas,Muhammet F. Gulen,Caini Liu,Natalia Giltiay,Hongwei Qin,LiPing Liu,Wen Qian,Richard M. Ransohoff,Cornelia C. Bergmann,Stephen A. Stohlman,Vincent K. Tuohy,Xiaoxia Li +12 more
TL;DR: Astroctyes are critical in IL-17-Act1-mediated leukocyte recruitment during autoimmune-induced inflammation of the CNS, and targeted Act1 deficiency in neuroectoderm-derived CNS-resident cells resulted in markedly reduced severity in EAE.
Journal ArticleDOI
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.
Muhammet F. Gulen,Zizhen Kang,Katarzyna Bulek,Wan Youzhong,Tae Whan Kim,Yi Chen,Cengiz Z. Altuntas,Kristian Sass Bak-Jensen,Mandy J. McGeachy,Jeong Su Do,Hui Xiao,Greg M. Delgoffe,Booki Min,Jonathan D. Powell,Vincent K. Tuohy,Daniel J. Cua,Xiaoxia Li,Xiaoxia Li +17 more
TL;DR: It is shown that SIGIRR, a negative regulator of IL-1 receptor and Toll-like receptor signaling, was induced during Th17 cell lineage commitment and governed Th 17 cell differentiation and expansion through its inhibitory effects on IL- 1 signaling.
Journal ArticleDOI
Act1 mediates IL-17–induced EAE pathogenesis selectively in NG2 + glial cells
Zizhen Kang,Chenhui Wang,Jarod A. Zepp,Ling Wu,Kevin Sun,Junjie Zhao,Unnikrishnan M. Chandrasekharan,Paul E. DiCorleto,Bruce D. Trapp,Richard M. Ransohoff,Xiaoxia Li +10 more
TL;DR: NG2+ glia is identified as the major CNS cellular target of IL-17 in EAE, and the sensitivity of oligodendrocyte lineage cells to IL- 17–mediated toxicity further suggests a direct link between inflammation and neurodegeneration in multiple sclerosis.
Journal ArticleDOI
The critical role of epithelial-derived Act1 in IL-17- and IL-25-mediated pulmonary inflammation
Shadi Swaidani,Katarzyna Bulek,Zizhen Kang,Caini Liu,Yi Lu,Weiguo Yin,Mark A. Aronica,Xiaoxia Li +7 more
TL;DR: The essential role of epithelial-derived Act1 is demonstrated for the understanding of pathobiology of atopic diseases, including allergic asthma, which identifies Act1 as a potential therapeutic target through the distinct impact of the IL-17R-Act1 and IL-25R- act1 axes.
Journal ArticleDOI
T cell-intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis
Bradley N. Martin,Bradley N. Martin,Chenhui Wang,Chenhui Wang,Cun Jin Zhang,Cun Jin Zhang,Zizhen Kang,Muhammet F. Gulen,Jarod A. Zepp,Junjie Zhao,Guanglin Bian,Jeong Su Do,Booki Min,Paul G. Pavicic,Caroline El-Sanadi,Paul L. Fox,Aoi Akitsu,Yoichiro Iwakura,Anasuya Sarkar,Mark D. Wewers,William J. Kaiser,Edward S. Mocarski,Marc E. Rothenberg,Amy G. Hise,George R. Dubyak,Richard M. Ransohoff,Xiaoxia Li +26 more
TL;DR: A critical role is revealed for IL-1β produced by a TH17 cell–intrinsic ASC–NLRP3–caspase-8 inflammasome during inflammation of the central nervous system.