C
Cun Jin Zhang
Researcher at Cleveland Clinic
Publications - 5
Citations - 277
Cun Jin Zhang is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Cellular differentiation & Inflammation. The author has an hindex of 4, co-authored 4 publications receiving 203 citations. Previous affiliations of Cun Jin Zhang include Tianjin Medical University & Tianjin Medical University General Hospital.
Papers
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Journal ArticleDOI
T cell-intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis
Bradley N. Martin,Bradley N. Martin,Chenhui Wang,Chenhui Wang,Cun Jin Zhang,Cun Jin Zhang,Zizhen Kang,Muhammet F. Gulen,Jarod A. Zepp,Junjie Zhao,Guanglin Bian,Jeong Su Do,Booki Min,Paul G. Pavicic,Caroline El-Sanadi,Paul L. Fox,Aoi Akitsu,Yoichiro Iwakura,Anasuya Sarkar,Mark D. Wewers,William J. Kaiser,Edward S. Mocarski,Marc E. Rothenberg,Amy G. Hise,George R. Dubyak,Richard M. Ransohoff,Xiaoxia Li +26 more
TL;DR: A critical role is revealed for IL-1β produced by a TH17 cell–intrinsic ASC–NLRP3–caspase-8 inflammasome during inflammation of the central nervous system.
Journal ArticleDOI
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
Chenhui Wang,Chenhui Wang,Cun Jin Zhang,Cun Jin Zhang,Bradley N. Martin,Bradley N. Martin,Katarzyna Bulek,Zizhen Kang,Zizhen Kang,Junjie Zhao,Guanglin Bian,Julie Carman,Ji Gao,Ashok Dongre,Haibo Xue,Stephen D. Miller,Youcun Qian,Dolores Hambardzumyan,Thomas A. Hamilton,Richard M. Ransohoff,Xiaoxia Li +20 more
TL;DR: Critical crosstalk between the IL-17 and NOTCH1 pathway is demonstrated, regulating Th17-induced inflammatory and proliferative genes to promote demyelinating disease.
Journal ArticleDOI
The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo
Caini Liu,Liang Zhu,Liang Zhu,Koichi Fukuda,Suidong Ouyang,Xing Chen,Chenhui Wang,Chenhui Wang,Cun Jin Zhang,Cun Jin Zhang,Bradley N. Martin,Chunfang Gu,Luke Qin,Rachakonda Suguna,Mark A. Aronica,Jun Qin,Jun Qin,Xiaoxia Li +17 more
TL;DR: The findings uncover a previously uncharacterized molecular mechanism of action of cyanidin, which may inform its further development into an effective small-molecule drug for the treatment of IL-17A–dependent inflammatory diseases and cancer.
Journal ArticleDOI
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3
Cun Jin Zhang,Cun Jin Zhang,Cun Jin Zhang,Chenhui Wang,Chenhui Wang,Meiling Jiang,Meiling Jiang,Chunfang Gu,Jianxin Xiao,Xing Chen,Bradley N. Martin,Fangqiang Tang,Erin Yamamoto,Yibo Xian,Han Wang,Fengling Li,R. Balfour Sartor,Howard Smith,M. Elaine Husni,Fu Dong Shi,Fu Dong Shi,Fu Dong Shi,Ji Gao,Julie Carman,Ashok Dongre,Susan C. McKarns,Ken Coppieters,Trine N. Jørgensen,Warren J. Leonard,Xiaoxia Li +29 more
TL;DR: It is shown that Act1 functions as a negative regulator in T and B cells via direct inhibition of STAT3, which might be an effective therapy for treating SLE- and Sjögren’s-like syndrome in patients containing Act1 mutation.
Journal ArticleDOI
Improvement of ε-Poly-l-lysine Production by Co-Culture Fermentation Strategy
Long Pan,Cun Jin Zhang,Xinyu Yuan,Yu Zhang,Xu-Sheng Chen,Cui-Cui Tian,Zisha Zhang,Mengliang Tian,Ai-Mei Liao,Guanghai Yu,Ming Hui,Xin Zeng,Jihong Huang +12 more
TL;DR: Wang et al. as discussed by the authors presented a co-culture fermentation strategy to enhance poly-poly-l-lysine (ε-PL) production, which screened a strain from five different strains that could be co-cultured with Streptomyces albulus to raise the production of poly-pl.