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Paul H. M. Savelkoul
Researcher at Maastricht University
Publications - 253
Citations - 12176
Paul H. M. Savelkoul is an academic researcher from Maastricht University. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 52, co-authored 233 publications receiving 10186 citations. Previous affiliations of Paul H. M. Savelkoul include Vanderbilt University Medical Center & University of Amsterdam.
Papers
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Journal ArticleDOI
Emergence of multidrug-resistant Gram-negative bacteria during selective decontamination of the digestive tract on an intensive care unit
Nashwan al Naiemi,Edou R. Heddema,Aldert Bart,Evert de Jonge,Christina M. J. E. Vandenbroucke-Grauls,Paul H. M. Savelkoul,Birgitta Duim +6 more
TL;DR: It is concluded that identification of emerging MDR Gram-negative bacteria and recognition of resistance plasmid transfer during SDD treatment are crucial for optimal application of this regimen in ICUs.
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Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants.
Birke J. Benedikter,Charlotte Volgers,Pascalle H. van Eijck,Emiel F.M. Wouters,Paul H. M. Savelkoul,Paul H. M. Savelkoul,Niki L. Reynaert,Guido R.M.M. Haenen,Gernot Rohde,Antje R. Weseler,Frank R. M. Stassen +10 more
TL;DR: Thiol‐reactive compounds like acrolein account for CSE‐induced exosome release by reacting with cell surface thiols, which may contribute to the clinical benefits of NAC treatment.
Journal ArticleDOI
Viral–bacterial interactions in the respiratory tract
Carla Bellinghausen,Gernot Rohde,Paul H. M. Savelkoul,Paul H. M. Savelkoul,Emiel F.M. Wouters,Frank R. M. Stassen +5 more
TL;DR: There is emerging evidence that persistent infection of the lower respiratory tract with potential pathogenic bacteria, as observed in diseases like chronic obstructive pulmonary disease or cystic fibrosis, modulates subsequent viral infections by increasing viral entry receptors and modulating the inflammatory response.
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Composition and diversity of the duodenal mucosa-associated microbiome in children with untreated coeliac disease.
T. G. J. de Meij,Andries E. Budding,Matthijs E. Grasman,C. M. F. Kneepkens,Paul H. M. Savelkoul,M. L. Mearin +5 more
TL;DR: Mucosa-associated duodenal microbiome composition and diversity did not differ between children with untreated CD and control children, and do not seem to play an important role in the pathogenesis of CD.
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Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation
Marlies J. Mooij,Eliana Drenkard,María A. Llamas,Christina M. J. E. Vandenbroucke-Grauls,Paul H. M. Savelkoul,Frederick M. Ausubel,Wilbert Bitter +6 more
TL;DR: Analysis of 48 clinical P. aeruginosa isolates showed no association between the presence of Pf1-like filamentous phages and the ability to form SCVs under static conditions; this suggests that filamentousphages are generally not involved in the emergence of P.aerug inosa SCVs.