P
Paul H. M. Savelkoul
Researcher at Maastricht University
Publications - 253
Citations - 12176
Paul H. M. Savelkoul is an academic researcher from Maastricht University. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 52, co-authored 233 publications receiving 10186 citations. Previous affiliations of Paul H. M. Savelkoul include Vanderbilt University Medical Center & University of Amsterdam.
Papers
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Journal ArticleDOI
Faecal Microbiota Dynamics and their Relation to Disease Course in Crohn's Disease
Gianluca Galazzo,Danyta I. Tedjo,Dion S J Wintjens,Dion S J Wintjens,Paul H. M. Savelkoul,Paul H. M. Savelkoul,Ad A.M. Masclee,Ad A.M. Masclee,Alexander Bodelier,Marie J. Pierik,Marie J. Pierik,Daisy Jonkers,Daisy Jonkers,John Penders +13 more
TL;DR: The altered microbiota composition and stability in CD was neither associated with disease activity nor long-term disease course, questioning its involvement in the development of an exacerbation.
Journal ArticleDOI
Neonatal microbiota development and the effect of early life antibiotics are determined by two distinct settler types
Anat Eck,Nicole B. Rutten,Maartje Singendonk,Ger T. Rijkers,Paul H. M. Savelkoul,Paul H. M. Savelkoul,Clemens B. Meijssen,Clarissa E. Crijns,Johanna H. Oudshoorn,Andries E. Budding,Arine M. Vlieger +10 more
TL;DR: It is hypothesize that stratification of children’s cohorts based on settler types may reveal group effects that might otherwise be masked in the first three months of life in term infants.
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Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles
Birke J. Benedikter,Freek G. Bouwman,Alexandra C.A. Heinzmann,Tanja Vajen,Edwin C. M. Mariman,Emiel F.M. Wouters,Paul H. M. Savelkoul,Paul H. M. Savelkoul,Rory R. Koenen,Gernot Rohde,Gernot Rohde,Rene van Oerle,Henri M. H. Spronk,Frank R. M. Stassen +13 more
TL;DR: Proteomic analysis allowed us to predict procoagulant properties of CSE-EVs which were confirmed in vitro and revealed that 24 proteins of the pathway haemostasis were significantly up-regulated in CSE, including TF.
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A new high-throughput AFLP approach for identification of new genetic polymorphism in the genome of the clonal microorganism Mycobacterium tuberculosis.
Nicole van den Braak,Guus Simons,Roy Gorkink,Martin Reijans,Kimberly Eadie,Kristin Kremers,Dick van Soolingen,Paul H. M. Savelkoul,Henri A. Verbrugh,Alex van Belkum +9 more
TL;DR: High-throughput amplified fragment length polymorphism (htAFLP) analysis to strains belonging to the five classical species of the Mycobacterium tuberculosis complex, finding that homologues for phage genes and insertion element-encoded genes were detected, confirming previous findings on the genetic heterogeneity within these genes.
Journal ArticleDOI
Optimal sampling time after preparation of platelet concentrates for detection of bacterial contamination by quantitative real-time polymerase chain reaction.
T. Mohammadi,Ruby N.I. Pietersz,L. A. H. Scholtalbers,Christina M. J. E. Vandenbroucke-Grauls,Paul H. M. Savelkoul,Henk W. Reesink +5 more
TL;DR: This real‐time PCR method was evaluated to determine the optimal sampling time for screening of bacterial contamination in PCs to detect bacterial contamination of platelet concentrates.