P
Paul Milman
Researcher at University of Toronto
Publications - 7
Citations - 1391
Paul Milman is an academic researcher from University of Toronto. The author has contributed to research in topics: Presenilin & Nicastrin. The author has an hindex of 6, co-authored 7 publications receiving 1370 citations. Previous affiliations of Paul Milman include University Health Network.
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Journal ArticleDOI
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
Gang Yu,Masaki Nishimura,Shigeki Arawaka,Shigeki Arawaka,Diane Levitan,Lili Zhang,Anurag Tandon,Anurag Tandon,You-Qiang Song,You-Qiang Song,Ekaterina Rogaeva,Ekaterina Rogaeva,Fusheng Chen,Fusheng Chen,Toshitaka Kawarai,Toshitaka Kawarai,Agnes Supala,Agnes Supala,Lyne Levesque,Lyne Levesque,Haung Yu,Haung Yu,Dun-Sheng Yang,Dun-Sheng Yang,Erin Holmes,Erin Holmes,Paul Milman,Paul Milman,Yan Liang,Yan Liang,Dong Mel Zhang,Dong Mel Zhang,Dong Hong Xu,Dong Hong Xu,Christine Sato,Christine Sato,Evgeny I. Rogaev,Evgeny I. Rogaev,Marsha Smith,Christopher Janus,Christopher Janus,Yanni Zhang,Ruedl Aebersold,Lindsay A. Farrer,Sandro Sorbl,Amalia C. Bruni,Paul E. Fraser,Paul E. Fraser,Peter St George-Hyslop,Peter St George-Hyslop +49 more
TL;DR: Nicastrin and presenilins are likely to be functional components of a multimeric complex necessary for the intramembranous proteolysis of proteins such as Notch/GLP-1 and βAPP.
Journal ArticleDOI
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex
Masaki Nishimura,Gang Yu,G. Levesque,D. M. Zhang,L. Ruel,Fusheng Chen,Paul Milman,Erin Holmes,Yan Liang,T. Kawakai,Euijung Jo,Agnes Supala,Ekaterina Rogaeva,D. M. Xu,Christopher Janus,Lyne Levesque,Q. Bi,Monika Duthie,Richard Rozmahel,Kari M. Mattila,Lars Lannfelt,David Westaway,Howard T.J. Mount,James R. Woodgett,Paul E. Fraser,P. St. George-Hyslop +25 more
TL;DR: It is reported here that presenilin mutations associated with familial Alzheimer disease (but not the non–pathogenic Glu318Gly polymorphism) alter the intracellular trafficking of β-catenin after activation of the Wnt/β- catenin signal transduction pathway.
Journal ArticleDOI
Nicastrin binds to membrane-tethered Notch
Fusheng Chen,Gang Yu,Shigeki Arawaka,Masaki Nishimura,Masaki Nishimura,Toshitaka Kawarai,Haung Yu,Anurag Tandon,Agnes Supala,You-Qiang Song,Ekaterina Rogaeva,Paul Milman,Christine Sato,Cong Yu,Christopher Janus,Julie Lee,Lixin Song,Lili Zhang,Paul E. Fraser,P. St. George-Hyslop,P. St. George-Hyslop +20 more
TL;DR: Nicastrin has a similar role in processing Notch and βAPP, but the 312–369 domain may have differential effects on these activities, and it is reported that the Notch or βAPP pathways do not significantly compete with each other.
Journal ArticleDOI
Mutation of Conserved Aspartates Affects Maturation of Both Aspartate Mutant and Endogenous Presenilin 1 and Presenilin 2 Complexes
Gang Yu,Fusheng Chen,Fusheng Chen,Masaki Nishimura,Masaki Nishimura,Harald Steiner,Anurag Tandon,Anurag Tandon,Toshitaka Kawarai,Toshitaka Kawarai,Shigeki Arawaka,Shigeki Arawaka,Agnes Supala,Agnes Supala,You-Qiang Song,You-Qiang Song,Ekaterina Rogaeva,Ekaterina Rogaeva,Erin Holmes,Erin Holmes,D. M. Zhang,D. M. Zhang,Paul Milman,Paul Milman,Paul E. Fraser,Paul E. Fraser,Christian Haass,Peter St George-Hyslop,Peter St George-Hyslop +28 more
TL;DR: The data suggest that the loss of function effects of the aspartate mutants result in altered PS complex maturation and argue that the functional presenilin moieties are contained in the high molecular weight complexes.
Journal ArticleDOI
Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.
Gang Yu,Fusheng Chen,Fusheng Chen,Masaki Nishimura,Masaki Nishimura,Harald Steiner,Anurag Tandon,Anurag Tandon,Toshitaka Kawarai,Toshitaka Kawarai,Shigeki Arawaka,Shigeki Arawaka,Agnes Supala,Agnes Supala,You-Qiang Song,You-Qiang Song,Ekaterina Rogaeva,Ekaterina Rogaeva,Erin Holmes,Erin Holmes,D. M. Zhang,D. M. Zhang,Paul Milman,Paul Milman,Paul E. Fraser,Paul E. Fraser,Christian Haass,P. St. George-Hyslop,P. St. George-Hyslop +28 more
TL;DR: The data suggest that the loss‐of‐function aspartate‐mutants cause altered PS complex maturation, and argue that the functional presenilin moieties are contained in the high molecular weight presenILin NTF/CTF‐containing complexes.