P
Paul S. Donnelly
Researcher at University of Melbourne
Publications - 215
Citations - 7933
Paul S. Donnelly is an academic researcher from University of Melbourne. The author has contributed to research in topics: Copper & Biodistribution. The author has an hindex of 45, co-authored 202 publications receiving 6785 citations. Previous affiliations of Paul S. Donnelly include University of Western Australia & University of Cambridge.
Papers
More filters
Journal ArticleDOI
Copper, gallium and zirconium positron emission tomography imaging agents: The importance of metal ion speciation
TL;DR: In this paper, a review of metal-based PET imaging agents with high radiochemical yields and purities requires careful consideration of the speciation of the metal ions in the presence of aqueous buffers and the physiological environment.
Journal ArticleDOI
Carboxymethylation of cage amines: control of alkylation by metal ion coordination.
TL;DR: All the new ligands have been characterized by X-ray structure determinations of their Cu(II) or Co(III) complexes and in some cases, this has shown that the methods used to isolate the crystalline complexes result in lactamization of the ligand.
Journal ArticleDOI
The challenges of using a copper fluorescent sensor (CS1) to track intracellular distributions of copper in neuronal and glial cells
Katherine A. Price,James L. Hickey,Zhiguang Xiao,Anthony G. Wedd,Simon James,Jeffrey R. Liddell,Peter J. Crouch,Anthony R. White,Paul S. Donnelly +8 more
TL;DR: In vitro characterization of CS1 suggests that, consistent with its relatively weak affinity for CuI, it is unlikely to compete with endogenous proteins with sub-picomolar affinities, nor with glutathione, the endogenous redox buffer essential for functional maintenance of many proteins, including those that bind CuI.
Journal ArticleDOI
Inhibition of TDP-43 Accumulation by Bis(thiosemicarbazonato)-Copper Complexes
Sarah J. Parker,Jodi Meyerowitz,Janine L. James,Jeffrey R. Liddell,Takashi Nonaka,Masato Hasegawa,Katja M. Kanninen,Sin Chun Lim,Brett M. Paterson,Paul S. Donnelly,Peter J. Crouch,Peter J. Crouch,Anthony R. White,Anthony R. White +13 more
TL;DR: It is found that treatment of cells and animal models of neurodegeneration, including an ALS model, with bioavailable bis(thiosemicarbazonato)copperII complexes (CuII(btsc)s) can modulate kinase activity and induce neuroprotective effects
Journal ArticleDOI
Bifunctional chelators for copper radiopharmaceuticals: the synthesis of [Cu(ATSM)–amino acid] and [Cu(ATSM)–octreotide] conjugates
TL;DR: Two new bifunctional chelators that are derivatives of the bis(thiosemicarbazone) ATSMH(2) proligand have been prepared and have the potential to be used for new targeted copper radiopharmaceuticals for imaging and therapy.