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Paul S. Donnelly
Researcher at University of Melbourne
Publications - 215
Citations - 7933
Paul S. Donnelly is an academic researcher from University of Melbourne. The author has contributed to research in topics: Copper & Biodistribution. The author has an hindex of 45, co-authored 202 publications receiving 6785 citations. Previous affiliations of Paul S. Donnelly include University of Western Australia & University of Cambridge.
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Journal ArticleDOI
Enzyme-Mediated Site-Specific Bioconjugation of Metal Complexes to Proteins: Sortase-Mediated Coupling of Copper-64 to a Single-Chain Antibody
Brett M. Paterson,Karen Alt,Charmaine M. Jeffery,Roger I. Price,Roger I. Price,Shweta Jagdale,Sheena Rigby,Charlotte C. Williams,Karlheinz Peter,Karlheinz Peter,Christoph E. Hagemeyer,Christoph E. Hagemeyer,Paul S. Donnelly +12 more
TL;DR: The enzyme-mediated site-specific bioconjugation of a radioactive metal complex to a single-chain antibody using the transpeptidase sortase A is reported and should be broadly applicable to other metal complexes and proteins.
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A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies.
Stacey E Rudd,Peter Roselt,Carleen Cullinane,Carleen Cullinane,Rodney J. Hicks,Rodney J. Hicks,Paul S. Donnelly +6 more
TL;DR: The new conjugates were radiolabeled with zirconium-89 to give complexes that are more resistant to ligand exchange when compared to currently used H3DFO derivatives and result in high quality positron emission tomography images in mouse models of HER2 positive breast cancer.
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Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.
Erin J. McAllum,Nastasia K. H. Lim,James L. Hickey,Brett M. Paterson,Paul S. Donnelly,Qiao-Xin Li,Jeffrey R. Liddell,Kevin J. Barnham,Kevin J. Barnham,Anthony R. White,Peter J. Crouch +10 more
TL;DR: Improved locomotor function and survival of SOD1-G37R mice supports the potential for CuII(atsm) as a novel treatment option for ALS.
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Mechanisms Controlling the Cellular Accumulation of Copper Bis(thiosemicarbazonato) Complexes
Katherine A. Price,Peter J. Crouch,Peter J. Crouch,Irene Volitakis,Brett M. Paterson,SinChun Lim,Paul S. Donnelly,Anthony R. White,Anthony R. White +8 more
TL;DR: The study delineates strategies to investigate the uptake and efflux mechanisms of metal complexes in cells, while highlighting specific difficulties and challenges that need to be considered before drawing definitive conclusions.
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Acetylacetonate bis(thiosemicarbazone) complexes of copper and nickel: towards new copper radiopharmaceuticals.
TL;DR: The nickel complexes are diamagnetic and the different coordination modes are confirmed in solution by NMR spectroscopy, and Electrochemical measurements show that the copper complexes undergo a reversible one-electron reduction at biologically accessible potentials.