Paul S. Donnelly

TL;DR: Twinkle twinkle quantum dot: Conjugation of biomolecules to azide-modified quantum dots (QDs) through a bifunctional linker, using strain-promoted azide -alkyne cycloaddition with the QD and a squaramide linkage to the biomolecule.

TL;DR: Reaction of [Cu(MeCN)(4)](+) with thiosemicarbazones bearing groups such as phenol, pyridine, or ferrocene gives tetranuclear or hexanuclear clusters with functional substituents; analogous air stable fluorescent clusters can also be prepared with Ag(I).

TL;DR: In this paper, the authors used a unique cell culture model, mitochondrial xenocybrids, to provide whole-cell mechanistic data on cellular retention of Cu from radiolabeled diacetylbis(4-methylthiosemicarbazonato)copperII [CuII(atsm)] for myocardial ischemia, hypoxic tumors, and brain disorders with regionalized oxidative stress, such as mitochondrial myopathy, encephalopathy, and lactic acidosis with stroke-like episodes (MELAS) and Parkinson's disease.

TL;DR: The new thiosemicarbazone-pyridylhydrazine based ligands that incorporate functional groups designed to bind amyloid-β plaques have been synthesized and provide insight into strategies to deliver metal complexes to amyloids- β plaques.

TL;DR: High late-retention in tumor and clearance from the liver suggest suitability for diagnostic studies and for prospective dosimetry for 67Cu-SARTATE peptide receptor radionuclide therapy, and the half-life of 64Cu would also facilitate good-manufacturing-practice production and distribution to sites without access to 68Ga.