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Paula Hoff
Researcher at Humboldt University of Berlin
Publications - 69
Citations - 1745
Paula Hoff is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Bone healing & Medicine. The author has an hindex of 18, co-authored 58 publications receiving 1220 citations. Previous affiliations of Paula Hoff include Leibniz Association & Charité.
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Journal ArticleDOI
A Pronounced Inflammatory Activity Characterizes the Early Fracture Healing Phase in Immunologically Restricted Patients
Paula Hoff,Timo Gaber,C. Strehl,M. Jakstadt,Holger Hoff,Katharina Schmidt-Bleek,Annemarie Lang,Eric Röhner,Dörte Huscher,Georg Matziolis,Gerd-Rüdiger Burmester,Gerhard Schmidmaier,Carsten Perka,Georg N. Duda,Frank Buttgereit +14 more
TL;DR: It is concluded here that the inflammatory activity on cellular and humoral levels at fracture sites of immunologically restricted patients considerably exceeds that of control patients.
Journal ArticleDOI
Inflammatory synovial fluid microenvironment drives primary human chondrocytes to actively take part in inflammatory joint diseases
Eric Röhner,Georg Matziolis,Carsten Perka,Bernd Füchtmeier,Timo Gaber,Gerd-Rüdiger Burmester,Frank Buttgereit,Paula Hoff +7 more
TL;DR: It is hypothesized that inflammatory synovial fluid triggers human chondrocytes to actively take part in inflammatory processes in rheumatic joint diseases and induces an active participation of chond rocytes in ongoing inflammation.
Journal ArticleDOI
Immunologically restricted patients exhibit a pronounced inflammation and inadequate response to hypoxia in fracture hematomas
Paula Hoff,Timo Gaber,Katharina Schmidt-Bleek,Ufuk Sentürk,Cam Loan Tran,K. Blankenstein,S. Lütkecosmann,J. Bredahl,H. J. Schüler,P. Simon,Georgi I. Wassilew,F. Unterhauser,G.-R. Burmester,Gerhard Schmidmaier,Carsten Perka,Georg N. Duda,Frank Buttgereit +16 more
TL;DR: It is demonstrated that cells within the fracture hematoma of immunologically restricted patients exhibit a disturbed osteogenic differentiation, show a strong inflammatory reaction, and react on local hypoxia on the way to a critical regeneration within the early inflammatory phase of fracture healing.
Journal ArticleDOI
Effects of PVA coated nanoparticles on human immune cells
C. Strehl,Timo Gaber,Lionel Maurizi,M. Hahne,R. Rauch,Paula Hoff,Thomas Häupl,Margarethe Hofmann-Amtenbrink,A. R. Poole,Heinrich Hofmann,Frank Buttgereit +10 more
TL;DR: An interaction between human immune cells and a-PVA-SPION is demonstrated which needs to be taken into account when considering the use of a- PVA- SPION in human medicine.
Journal ArticleDOI
Impact of the CTLA‐4/CD28 axis on the processes of joint inflammation in rheumatoid arthritis
Dezsö Körmendy,Holger Hoff,Paula Hoff,Barbara M. Bröker,Gerd-Rüdiger Burmester,Monika C. Brunner-Weinzierl +5 more
TL;DR: The ex vivo and in vitro results demonstrate that the CTLA-4/CD28 axis constitutes a drug target for not only the systemic, but potentially also the local, application of the costimulation blocking agent CTla-4Ig for the treatment of RA.