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Paula Hoff
Researcher at Humboldt University of Berlin
Publications - 69
Citations - 1745
Paula Hoff is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Bone healing & Medicine. The author has an hindex of 18, co-authored 58 publications receiving 1220 citations. Previous affiliations of Paula Hoff include Leibniz Association & Charité.
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Journal ArticleDOI
JAK/STAT Activation: A General Mechanism for Bone Development, Homeostasis, and Regeneration
TL;DR: The role of JAK/STAT pathway on development, homeostasis, and regeneration is summarized based on skeletal phenotype of individual JAK and STAT gene knockout models and selective inhibition of components of the Jak/STAT signaling including influences of Jak inhibition in osteoclasts, osteoblasts, and osteocytes.
Journal ArticleDOI
Preoperative irradiation for the prevention of heterotopic ossification induces local inflammation in humans.
Paula Hoff,Anastasia Rakow,Timo Gaber,M. Hahne,Ufuk Sentürk,C. Strehl,Monique Fangradt,Katharina Schmidt-Bleek,Dörte Huscher,Tobias Winkler,Dörte Matziolis,Georg Matziolis,Harun Badakhshi,Gerd-Rüdiger Burmester,Georg N. Duda,Carsten Perka,Frank Buttgereit +16 more
TL;DR: It is concluded that preoperative irradiation results in significant changes in immune cell composition and cytokine secretion in THA-hematomas, establishing a specific - rather proinflammatory - milieu.
Journal Article
Effects of treatment with etanercept versus methotrexate on sleep quality, fatigue and selected immune parameters in patients with active rheumatoid arthritis.
Jacqueline Detert,René Dziurla,Paula Hoff,Timo Gaber,Pascal Klaus,Hans Bastian,T. Braun,Saskia Schellmann,Thomas Penzel,Ingo Fietze,Peter-Andreas Loeschmann,Peter Jaehnig,Rainer H. Straub,Gerd R Burmester,Frank Buttgereit +14 more
TL;DR: Both therapies improved disease activity, CRP, SF-36 and HAQ-DI, with faster, more pronounced changes in DAS28CRP in the ETA group, which alone had significantly improved sleep parameters.
Journal ArticleDOI
Disentangling the effects of tocilizumab on neutrophil survival and function.
Timo Gaber,M. Hahne,C. Strehl,Paula Hoff,Yvonne Dörffel,Eugen Feist,Gerd-Rüdiger Burmester,Frank Buttgereit +7 more
TL;DR: The results suggest that both effects can at least in part be explained by a reduction in neutrophil survival, a dose-dependent inhibition of hypoxia-induced NADPH oxidase-mediated oxidative burst and phagocytosis of infiltrating hypoxic neutrophils and an alteration of mediator secretion.
Journal ArticleDOI
Preferred use of polyhexanide in orthopedic surgery.
Eric Röhner,Jörn Bengt Seeger,Paula Hoff,Tilman Pfitzner,Bernd Preininger,Kristin Andreas,Frank Buttgereit,Carsten Perka,Georg Matziolis +8 more
TL;DR: The data show that poly hexanide promotes apoptosis on primary human chondrocytes in vitro, which may indicate the use of polyhexanide in septic joint surgery.