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Paula Mera
Researcher at University of Barcelona
Publications - 28
Citations - 1323
Paula Mera is an academic researcher from University of Barcelona. The author has contributed to research in topics: Osteocalcin & GPRC6A. The author has an hindex of 13, co-authored 26 publications receiving 902 citations. Previous affiliations of Paula Mera include Columbia University Medical Center & Columbia University.
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Journal ArticleDOI
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise.
Paula Mera,Kathrin Laue,Mathieu Ferron,Cyril Confavreux,Jianwen Wei,Marta Galán-Díez,Alain Lacampagne,Sarah J. Mitchell,Julie A. Mattison,Yun Chen,Justine Bacchetta,Pawel Szulc,Richard N. Kitsis,Rafael de Cabo,Richard A. Friedman,Christopher Torsitano,Timothy E. McGraw,Michelle Puchowicz,Irwin J. Kurland,Gerard Karsenty +19 more
TL;DR: This study uncovers a bone-to-muscle feedforward endocrine axis that favors adaptation to exercise and can reverse the age-induced decline in exercise capacity.
Journal ArticleDOI
Mitochondrial Fatty Acid Oxidation in Obesity
TL;DR: This review evaluates recent discoveries regarding mitochondrial fatty acid oxidation (FAO) and its potential as a therapy for obesity, focusing on the still controversial beneficial effects of increased FAO in liver and muscle.
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Gpr158 mediates osteocalcin's regulation of cognition.
Lori Khrimian,Arnaud Obri,Mariana Ramos-Brossier,Mariana Ramos-Brossier,Audrey Rousseaud,Audrey Rousseaud,Stéphanie Moriceau,Stéphanie Moriceau,Anne-Sophie Nicot,Anne-Sophie Nicot,Paula Mera,Stylianos Kosmidis,Stylianos Kosmidis,Stylianos Kosmidis,Theodoros Karnavas,Frédéric Saudou,Frédéric Saudou,Xiao-Bing Gao,Franck Oury,Franck Oury,Eric R. Kandel,Gerard Karsenty +21 more
TL;DR: It is shown that the presence ofOCN is necessary for the beneficial influence of plasma from young mice when injected into older mice on memory and that peripheral delivery of OCN is sufficient to improve memory and decrease anxiety-like behaviors in 16-mo-old mice.
Journal ArticleDOI
Osteocalcin is necessary and sufficient to maintain muscle mass in older mice
TL;DR: It is found that osteocalcin signaling in myofibers is necessary to maintain muscle mass in older mice in part because it promotes protein synthesis in myotubes without affecting protein breakdown.
Journal ArticleDOI
Molecular bases of the crosstalk between bone and muscle
Gerard Karsenty,Paula Mera +1 more
TL;DR: These studies have revealed a feed-forward loop between bone and skeletal muscle that are necessary and sufficient for optimum exercise capacity and suggest novel and adapted strategies for the prevention or treatment of age related muscle loss.