M
Mathieu Ferron
Researcher at Université de Montréal
Publications - 67
Citations - 10258
Mathieu Ferron is an academic researcher from Université de Montréal. The author has contributed to research in topics: Osteocalcin & Insulin. The author has an hindex of 31, co-authored 62 publications receiving 9025 citations. Previous affiliations of Mathieu Ferron include McGill University & Columbia University Medical Center.
Papers
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Journal ArticleDOI
Endocrine Regulation of Energy Metabolism by the Skeleton
Na Kyung Lee,Hideaki Sowa,Eiichi Hinoi,Mathieu Ferron,Jong Deok Ahn,Cyrille Confavreux,Romain Dacquin,Patrick J. Mee,Marc D. McKee,Dae Young Jung,Zhiyou Zhang,Jason K. Kim,Franck Mauvais-Jarvis,Patricia Ducy,Gerard Karsenty +14 more
TL;DR: It is shown that mice lacking the protein tyrosine phosphatase OST-PTP are hypoglycemic and are protected from obesity and glucose intolerance because of an increase in beta-cell proliferation, insulin secretion, and insulin sensitivity, and in vivo osteocalcin can improve glucose tolerance.
Journal ArticleDOI
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
Carmine Settembre,Carmine Settembre,Roberto Zoncu,Diego L. Medina,Francesco Vetrini,Francesco Vetrini,Serkan Erdin,SerpilUckac Erdin,SerpilUckac Erdin,Tuong Huynh,Tuong Huynh,Mathieu Ferron,Gerard Karsenty,Michel C. Vellard,Valeria Facchinetti,David M. Sabatini,Andrea Ballabio +16 more
TL;DR: It is shown that the Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis, colocalizes with master growth regulator mTOR complex 1 (mTORC1) on the lysOSomal membrane and the Rag GTPase complex is both necessary and sufficient to regulate starvation‐ and stress‐induced nuclear translocation of TFEB.
Journal ArticleDOI
Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism
Mathieu Ferron,Jianwen Wei,Tatsuya Yoshizawa,Andrea Del Fattore,Ronald A. DePinho,Anna Teti,Patricia Ducy,Gerard Karsenty +7 more
TL;DR: It is shown here that insulin signaling in osteoblasts is necessary for whole-body glucose homeostasis because it increases osteocalcin activity, which promotes glucose metabolism in a bone resorption-dependent manner in mice and humans.
Journal ArticleDOI
Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
TL;DR: It is shown that long-term treatment of WT mice with osteocalcin can significantly weaken the deleterious effect on body mass and glucose metabolism of gold thioglucose-induced hyperphagia and high-fat diet and suggest that osteocalin may be of value in the treatment of metabolic diseases.
Journal ArticleDOI
Endocrine regulation of male fertility by the skeleton
Franck Oury,Grzegorz Sumara,Olga Sumara,Mathieu Ferron,Haixin Chang,Charles E. Smith,Louis Hermo,Susan S. Suarez,Bryan L. Roth,Patricia Ducy,Gerard Karsenty +10 more
TL;DR: It is shown that, in males, bone acts as a regulator of fertility, and the physiological repertoire of osteocalcin is expanded, providing the first evidence that the skeleton is an endocrine regulator of reproduction.