P
Paulina M. Strzelecka
Researcher at University of Cambridge
Publications - 17
Citations - 999
Paulina M. Strzelecka is an academic researcher from University of Cambridge. The author has contributed to research in topics: Progenitor cell & Haematopoiesis. The author has an hindex of 7, co-authored 16 publications receiving 502 citations. Previous affiliations of Paulina M. Strzelecka include German Cancer Research Center & Charité.
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Journal ArticleDOI
A cellular census of human lungs identifies novel cell states in health and in asthma.
Felipe A. Vieira Braga,Gozde Kar,Marijn Berg,Orestes A Carpaij,Krzysztof Polanski,Lukas M. Simon,Sharon Brouwer,Tomás Gomes,Laura Hesse,Jian Jiang,Eirini S. Fasouli,Mirjana Efremova,Roser Vento-Tormo,Carlos Talavera-López,Marnix R. Jonker,Karen Affleck,Subarna Palit,Paulina M. Strzelecka,Paulina M. Strzelecka,Helen V. Firth,Krishnaa T. Mahbubani,Ana Cvejic,Ana Cvejic,Kerstin B. Meyer,Kourosh Saeb-Parsy,Marjan Luinge,Corry-Anke Brandsma,Wim Timens,Ilias Angelidis,Maximilian Strunz,Gerard H. Koppelman,Antoon J. M. van Oosterhout,Herbert B. Schiller,Fabian J. Theis,Maarten van den Berge,Martijn C. Nawijn,Sarah A. Teichmann,Sarah A. Teichmann +37 more
TL;DR: Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs.
Journal ArticleDOI
Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis
Anna Maria Ranzoni,Andrea Tangherloni,Andrea Tangherloni,Andrea Tangherloni,Ivan Berest,Simone Giovanni Riva,Simone Giovanni Riva,Simone Giovanni Riva,Brynelle Myers,Paulina M. Strzelecka,Jiarui Xu,Jiarui Xu,Jiarui Xu,Elisa Panada,Elisa Panada,Irina Mohorianu,Judith B. Zaugg,Ana Cvejic,Ana Cvejic,Ana Cvejic +19 more
TL;DR: In this paper, the authors applied single-cell RNA sequencing (scRNA-seq) and single cell assay for transposase-accessible chromatin sequencing to over 8,000 human immunophenotypic blood cells from fetal liver and bone marrow.
Posted ContentDOI
Integrative Single-cell RNA-Seq and ATAC-Seq Analysis of Human Foetal Liver and Bone Marrow Haematopoiesis
Anna Maria Ranzoni,Anna Maria Ranzoni,Anna Maria Ranzoni,Andrea Tangherloni,Andrea Tangherloni,Andrea Tangherloni,Ivan Berest,Simone Giovanni Riva,Simone Giovanni Riva,Simone Giovanni Riva,Brynelle Myers,Brynelle Myers,Paulina M. Strzelecka,Paulina M. Strzelecka,Paulina M. Strzelecka,Jiarui Xu,Jiarui Xu,Jiarui Xu,Elisa Panada,Elisa Panada,Irina Mohorianu,Judith B. Zaugg,Ana Cvejic,Ana Cvejic,Ana Cvejic +24 more
TL;DR: This study applied single-cell (sc)RNA-Seq and scATAC-Sequ analysis to over 8,000 human immunophenotypic blood cells from foetal liver and bone marrow and identified three highly proliferative oligopotent progenitor populations downstream from haematopoietic stem cell/multipotent progensitors (HSC/MPPs).
Journal ArticleDOI
Single-cell transcriptional analysis reveals ILC-like cells in zebrafish
Pedro P. Hernandez,Pedro P. Hernandez,Paulina M. Strzelecka,Paulina M. Strzelecka,Paulina M. Strzelecka,Emmanouil Athanasiadis,Emmanouil Athanasiadis,Emmanouil Athanasiadis,Dominic Hall,Ana F. Robalo,Ana F. Robalo,Catherine Collins,Pierre Boudinot,Jean-Pierre Levraud,Jean-Pierre Levraud,Ana Cvejic,Ana Cvejic,Ana Cvejic +17 more
TL;DR: A comprehensive atlas of zebrafish lymphocytes during tissue homeostasis and after immune challenge is generated and a rorc-positive subset of ILCs that could express cytokines associated with type 1, 2, and 3 responses upon immune challenge are uncovered.
Journal ArticleDOI
Dissecting human disease with single-cell omics: application in model systems and in the clinic.
Paulina M. Strzelecka,Paulina M. Strzelecka,Paulina M. Strzelecka,Anna Maria Ranzoni,Anna Maria Ranzoni,Anna Maria Ranzoni,Ana Cvejic +6 more
TL;DR: The current state of the art of single-cell techniques and their potential applications in deciphering the heterogeneous nature of diseases and tailoring personalised therapies are summarized.