P
Paulina Roux-Biejat
Researcher at University of Milan
Publications - 5
Citations - 48
Paulina Roux-Biejat is an academic researcher from University of Milan. The author has contributed to research in topics: Skeletal muscle & Regeneration (biology). The author has an hindex of 2, co-authored 4 publications receiving 16 citations.
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Journal ArticleDOI
Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle
Matteo Giovarelli,Silvia Zecchini,Emanuele Martini,Massimiliano Garrè,Sara Barozzi,Michela Ripolone,Laura Napoli,Marco Coazzoli,Chiara Vantaggiato,Paulina Roux-Biejat,Davide Cervia,Claudia Moscheni,Cristiana Perrotta,Dario Parazzoli,Emilio Clementi,Emilio Clementi,Clara De Palma +16 more
TL;DR: It is demonstrated that Drp1 is involved in this process of marked mitochondria repositioning in muscle fibres and altered desmin architecture impairs mechanotransduction and compromises mitochondrial network stability priming mitochondria transport through microtubule-dependent trafficking with a mechanism that involves theDrp1-dependent regulation of kinesin-1 complex.
Journal ArticleDOI
Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy.
Matteo Giovarelli,Silvia Zecchini,Giorgia Catarinella,Claudia Moscheni,Patrizia Sartori,Cecilia Barbieri,Paulina Roux-Biejat,Alessandra Napoli,Chiara Vantaggiato,Davide Cervia,Cristiana Perrotta,Emilio Clementi,Emilio Clementi,Lucia Latella,Clara De Palma +14 more
TL;DR: In this paper, Givinostat was shown to positively modify the epigenetic profile of peroxisome proliferator-activated receptor-gamma coactivator 1 α (PGC-1α) promoter, sustaining mitochondrial biogenesis and oxidative fiber type switch.
Journal ArticleDOI
Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma.
Marco Coazzoli,Alessandra Napoli,Paulina Roux-Biejat,Clara De Palma,Claudia Moscheni,Elisabetta Catalani,Silvia Zecchini,Vincenzo Conte,Matteo Giovarelli,Sonia Caccia,Patrizia Procacci,Davide Cervia,Emilio Clementi,Cristiana Perrotta +13 more
TL;DR: The reduction of A-SMase expression, observed in malignant melanomas, may determine their metastatic behaviour through the stimulation of mitochondrial fusion, activity and biogenesis, conferring a metabolic advantage to melanoma cells.
Journal ArticleDOI
Acid Sphingomyelinase Controls Early Phases of Skeletal Muscle Regeneration by Shaping the Macrophage Phenotype
Paulina Roux-Biejat,Marco Coazzoli,Pasquale Marrazzo,Silvia Zecchini,Ilaria Di Renzo,Cecilia Prata,Alessandra Napoli,Claudia Moscheni,Matteo Giovarelli,Maria Cristina Barbalace,Elisabetta Catalani,Maria Teresa Bassi,Clara De Palma,Davide Cervia,Marco Malaguti,Silvana Hrelia,Emilio Clementi,Cristiana Perrotta +17 more
TL;DR: In this article, acid sphingomyelinase (ASMase) was found to be activated after skeletal muscle injury induced in vivo by the injection of cardiotoxin, and the role of ASMase in regulating immune response during muscle regeneration/repair was investigated.
Journal ArticleDOI
RACK1 is evolutionary conserved in satellite stem cell activation and adult skeletal muscle regeneration
Elisabetta Catalani,Silvia Zecchini,Matteo Giovarelli,Agnese Cherubini,Simona Del Quondam,Kashi Brunetti,Federica Silvestri,Paulina Roux-Biejat,Alessandra Napoli,Silvia Rosanna Casati,Marcello Ceci,Nicla Romano,Silvia Bongiorni,Giorgio Prantera,Emilio Clementi,Cristiana Perrotta,Clara De Palma,Davide Cervia +17 more
TL;DR: In this paper , the Receptor for Activated C-Kinase 1 (RACK1) was found to be important for skeletal muscle regeneration in both mouse and fruit fly.